Maternal obesity and ancestry distance in influencing birth outcomes.

IF 4.2 2区医学 Q1 ENDOCRINOLOGY & METABOLISM

International Journal of Obesity Pub Date : 2025-04-12 DOI:10.1038/s41366-025-01783-9

Randy Le, Richard J Biedrzycki, Fasil Tekola-Ayele

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引用次数: 0

Abstract

Background: Maternal pre-pregnancy obesity has been associated with birth outcomes, but the influence of genetic distance (GD) on this relationship is unclear. Therefore, the objective of this study was to assess the interplay of GD and maternal obesity on birthweight, placental weight, and large for gestational age (LGA).

Methods: We used data from the NICHD Fetal Growth Studies-Singletons cohort, a prospective cohort study of multi-ancestral pregnant women. GD was estimated using data from 1810 women across four ancestral reference populations. We categorized GD into five quintiles, with quintile one and quintile five representing the closest and farthest distances, respectively. Linear regression models were used to test association between GD and birth outcomes and to estimate the association of interaction of GD and maternal obesity with birth outcomes.

Results: Farther maternal GD from an African reference was significantly associated with higher birthweight and higher odds of LGA, with associations persisting after adjusting for socioeconomic status (SES). The interaction between the third Amerindigenous GD quintile and obesity was significantly associated with a 198 g larger placental weight (95% CI = 51-345, p = 0.009) compared to the first Amerindigenous GD quintile. We also found the interaction between East Asian fourth GD quintile and obesity to be significantly associated with 86.0% lower odds of infants being born LGA (OR = 0.14 g, 95% CI = 0.02-74, p = 0.031) compared to the first quintile. These associations persisted after SES adjustment.

Conclusions: Interplays between maternal GD from Amerindigenous and East Asian references and pre-pregnancy obesity influence placental weight and risk of LGA. The results underline that consideration of maternal obesity in the context of GD from multiple ancestries and SES may facilitate interventions that will minimize adverse pregnancy outcomes.

Clinical trial registration: The study has been registered at ClinicalTrials.gov (Trial registration: NCT00912132).

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母亲肥胖和祖先距离对出生结果的影响。

背景：孕妇孕前肥胖与分娩结局相关，但遗传距离（GD）在这一关系中的影响尚不清楚。因此，本研究的目的是评估GD和母亲肥胖对出生体重、胎盘体重和胎龄大（LGA）的相互作用。方法：我们使用来自NICHD胎儿生长研究-单胎队列的数据，这是一项多祖先孕妇的前瞻性队列研究。使用来自四个祖先参考人群的1810名妇女的数据估计GD。我们将GD分为五个五分位数，其中五分位数1和五分位数5分别代表最近和最远的距离。使用线性回归模型检验GD与出生结局之间的关系，并估计GD和母亲肥胖与出生结局的相互作用的关系。结果：离非洲更远的母亲GD与更高的出生体重和更高的LGA几率显著相关，在调整社会经济地位（SES）后，这种关联仍然存在。与第一个美洲原住民GD五分位数相比，第三个美洲原住民GD五分位数与肥胖之间的相互作用与胎盘重量增加198 g显著相关（95% CI = 51-345, p = 0.009）。我们还发现东亚第四个GD五分位数与肥胖之间的相互作用显著相关，与第一个五分位数相比，婴儿出生时患有LGA的几率低86.0% （OR = 0.14 g, 95% CI = 0.02-74, p = 0.031）。这些关联在SES调整后仍然存在。结论：来自美洲和东亚参考文献的产妇GD与孕前肥胖之间的相互作用影响胎盘重量和LGA的风险。结果强调，在多祖先GD和SES背景下考虑母亲肥胖可能有助于减少不良妊娠结局的干预措施。临床试验注册：该研究已在ClinicalTrials.gov上注册（试验注册号：NCT00912132）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Obesity 医学-内分泌学与代谢

CiteScore

10.00

自引率

2.00%

发文量

221

审稿时长

3 months

期刊介绍： The International Journal of Obesity is a multi-disciplinary forum for research describing basic, clinical and applied studies in biochemistry, physiology, genetics and nutrition, molecular, metabolic, psychological and epidemiological aspects of obesity and related disorders. We publish a range of content types including original research articles, technical reports, reviews, correspondence and brief communications that elaborate on significant advances in the field and cover topical issues.