[Establishment and application progress of deaf animal models].

Abstract

Deafness as the most prevalent sensory defect disease, seriously affects personal life and social development, and is a major public health challenge that needs to be addressed urgently. Occupational noise-induced deafness has become the second most common occupational disease in China and has attracted much attention. Relevant animal experimental studies can provide a basis for the prevention and control of the disease. This article respectively introduces the animal strain selection, modeling methods, model identification indicators, and model applications of animal models for conductive deafness, sensorineural deafness, and mixed deafness. The aim is to provide references for establishing different types of deafness animal models and to offer scientific tools for in-depth research on the pathological mechanisms, treatment strategies, and drug screening of various types of deafness.