Backbone Conditional Protein Sequence Design.

IF 6.9 2区 生物学 Q1 CELL BIOLOGY
Justas Dauparas
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引用次数: 0

Abstract

A protein is defined by its amino acid sequence. This sequence and environmental factors shape a protein's 3D structural landscape, which is crucial for the protein's function and activity. Protein design aims to develop novel protein sequences or modify existing ones to perform specific functions or have desired protein properties. The protein sequence space is exponentially large, making protein sequence design a tough problem. This problem can be simplified by considering a backbone conditional protein sequence design that factorizes the design problem into two parts: protein backbone design and backbone-dependent sequence design. This allows for a more efficient search over the sequence space for desired structural features. In this review, we discuss when backbone conditional sequence design is possible and how to assess the performance of different design methods, training data, symmetric design, and the combination of unconditional and conditional sequence models.

主干条件蛋白序列设计。
蛋白质是由它的氨基酸序列决定的。这个序列和环境因素塑造了蛋白质的三维结构景观,这对蛋白质的功能和活性至关重要。蛋白质设计旨在开发新的蛋白质序列或修改现有的蛋白质序列以执行特定功能或具有所需的蛋白质特性。蛋白质序列空间呈指数级增长,使得蛋白质序列设计成为一个难题。考虑有条件的蛋白质序列设计可以简化这一问题,该设计将蛋白质序列设计分为两部分:蛋白质骨架设计和依赖于骨架的序列设计。这允许在序列空间中更有效地搜索所需的结构特征。在这篇综述中,我们讨论了什么情况下骨干条件序列设计是可能的,以及如何评估不同的设计方法、训练数据、对称设计以及无条件和条件序列模型的组合的性能。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
15.00
自引率
1.40%
发文量
56
审稿时长
3-8 weeks
期刊介绍: Cold Spring Harbor Perspectives in Biology offers a comprehensive platform in the molecular life sciences, featuring reviews that span molecular, cell, and developmental biology, genetics, neuroscience, immunology, cancer biology, and molecular pathology. This online publication provides in-depth insights into various topics, making it a valuable resource for those engaged in diverse aspects of biological research.
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