Targeting risk factors for false-positive outcomes in newborn hearing screening: a focus on mode of delivery - a case-control study.

IF 2.2 3区 医学 Q2 OTORHINOLARYNGOLOGY
Sivan Farladansky-Gershnabel, Liron Kariv, Hanoch Schreiber, Dorit Ravid, Gal Cohen, Tal Biron-Shental, Michal Kovo, Racheli Edelman Krivoshey, Shmuel Arnon
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Abstract

Purpose: Otoacoustic emission (OAE) is a widely utilized method for screening newborns for congenital hearing loss. While OAE-based screening has high sensitivity, it is associated with high false-positive rates when conducted shortly after birth. Previous studies found that infants delivered by cesarean section show higher false-positive rates. Nonetheless, other modes of delivery have not been investigated to date. This study aims to evaluate the impact of maternal, neonatal, and perinatal factors on hearing screening false-positive results.

Methods: This retrospective study included 5,621 infants with normal hearing. Infants were divided into two groups: those who failed the initial OAE hearing screening were assigned to the study group, and those who passed were assigned to the control group. Maternal, neonatal, and perinatal factors were extracted from medical records and analyzed to assess possible associations with failing the initial OAE screening.

Results: A total of 365 out of 5621 (6.5%) neonates failed the initial OAE hearing screening. The study group had a higher prevalence of infants delivered by elective or emergency cesarean section, as well as by vacuum-assisted delivery, compared to the control group. Multivariate analysis showed that the mode of delivery had a significant effect on false-positive results, with odds ratios of 15.5, 7.2, and 8.6 for infants born by elective cesarean section, emergency cesarean section, and vacuum delivery, respectively, compared to vaginal delivery.

Conclusion: Infants delivered by cesarean section or vacuum extraction have higher odds of failing the initial OAE screening when conducted within 48-72 h after birth. Further research is needed to determine the optimal timing for hearing screening.

针对新生儿听力筛查中假阳性结果的危险因素:对分娩方式的关注-一项病例对照研究。
目的:耳声发射(OAE)是一种广泛应用于新生儿先天性听力损失筛查的方法。虽然基于oae的筛查具有高灵敏度,但在出生后不久进行筛查时,其假阳性率较高。先前的研究发现,剖腹产婴儿的假阳性率更高。尽管如此,迄今为止尚未对其他交付方式进行调查。本研究旨在评估产妇、新生儿和围产期因素对听力筛查假阳性结果的影响。方法:对5621名听力正常的婴儿进行回顾性研究。婴儿被分为两组:未通过最初OAE听力筛查的婴儿被分配到研究组,通过的婴儿被分配到对照组。从医疗记录中提取孕产妇、新生儿和围产期因素,并对其进行分析,以评估与初始OAE筛查失败的可能关联。结果:5621例新生儿中有365例(6.5%)未通过初始OAE听力筛查。与对照组相比,研究组通过选择性或紧急剖宫产以及真空辅助分娩分娩的婴儿患病率更高。多因素分析显示,分娩方式对假阳性结果有显著影响,与阴道分娩相比,选择剖宫产、紧急剖宫产和真空分娩出生的婴儿的优势比分别为15.5、7.2和8.6。结论:剖宫产或真空抽吸出生的婴儿在出生后48 ~ 72 h内进行初始OAE筛查失败的几率较高。需要进一步的研究来确定听力筛查的最佳时机。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
5.30
自引率
7.70%
发文量
537
审稿时长
2-4 weeks
期刊介绍: Official Journal of European Union of Medical Specialists – ORL Section and Board Official Journal of Confederation of European Oto-Rhino-Laryngology Head and Neck Surgery "European Archives of Oto-Rhino-Laryngology" publishes original clinical reports and clinically relevant experimental studies, as well as short communications presenting new results of special interest. With peer review by a respected international editorial board and prompt English-language publication, the journal provides rapid dissemination of information by authors from around the world. This particular feature makes it the journal of choice for readers who want to be informed about the continuing state of the art concerning basic sciences and the diagnosis and management of diseases of the head and neck on an international level. European Archives of Oto-Rhino-Laryngology was founded in 1864 as "Archiv für Ohrenheilkunde" by A. von Tröltsch, A. Politzer and H. Schwartze.
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