Xiaojie Lin, Lanlan Jiang, Qiaozhi Jiang, Qixin Zeng, Zuke Ya, Xiangzhi Yong, Guocheng Mei, Yuxiao Huang, Juanxiu Su, Renchuan Tao
{"title":"Combined Proteomic and Metabolomic Analysis of Cognitive Impairment in Patients With Burning Mouth Syndrome.","authors":"Xiaojie Lin, Lanlan Jiang, Qiaozhi Jiang, Qixin Zeng, Zuke Ya, Xiangzhi Yong, Guocheng Mei, Yuxiao Huang, Juanxiu Su, Renchuan Tao","doi":"10.1111/joor.14003","DOIUrl":null,"url":null,"abstract":"<p><strong>Background and objective: </strong>Burning mouth syndrome (BMS) is considered a multifactorial condition. The study aimed to investigate the association between BMS and cognitive impairment (CI), as well as the proteomic and metabolomic characteristics.</p><p><strong>Materials and methods: </strong>A total of 42 BMS patients and 23 healthy controls were recruited from August 2022 to August 2024 to analyse the relationship between BMS, psychological factors and cognitive function. Saliva samples were collected for comprehensive proteomic and metabolomic analyses, followed by validation studies.</p><p><strong>Results: </strong>The mini-mental state examination (MMSE) indicated a significantly higher prevalence of CI in the BMS group (50.00%) compared to the healthy control group (8.70%) (p = 0.001). Logistic regression analysis revealed that BMS incidence was negatively correlated with MMSE scores and positively correlated with depression scores (both p < 0.05). Proteomics and metabolomics identified 197 differential proteins and 208 differential metabolites in the BMS group relative to the healthy control group. Additionally, there were 407 differential proteins and 344 differential metabolites in the BMS with cognitive impairment (BC) group compared to the BMS with noncognitive impairment (BnC) group. Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis of combined proteomics and metabolomics data revealed the involvement of the arachidonic acid metabolic pathway and salivary secretion pathway in BMS and CI respectively.</p><p><strong>Conclusion: </strong>Higher levels of depression and lower cognitive function appear to be more closely associated with BMS. The pathways of arachidonic acid metabolism and salivary secretion may play significant roles in the pathogenesis of BMS and CI respectively.</p>","PeriodicalId":16605,"journal":{"name":"Journal of oral rehabilitation","volume":" ","pages":""},"PeriodicalIF":3.1000,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of oral rehabilitation","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1111/joor.14003","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"DENTISTRY, ORAL SURGERY & MEDICINE","Score":null,"Total":0}
引用次数: 0
Abstract
Background and objective: Burning mouth syndrome (BMS) is considered a multifactorial condition. The study aimed to investigate the association between BMS and cognitive impairment (CI), as well as the proteomic and metabolomic characteristics.
Materials and methods: A total of 42 BMS patients and 23 healthy controls were recruited from August 2022 to August 2024 to analyse the relationship between BMS, psychological factors and cognitive function. Saliva samples were collected for comprehensive proteomic and metabolomic analyses, followed by validation studies.
Results: The mini-mental state examination (MMSE) indicated a significantly higher prevalence of CI in the BMS group (50.00%) compared to the healthy control group (8.70%) (p = 0.001). Logistic regression analysis revealed that BMS incidence was negatively correlated with MMSE scores and positively correlated with depression scores (both p < 0.05). Proteomics and metabolomics identified 197 differential proteins and 208 differential metabolites in the BMS group relative to the healthy control group. Additionally, there were 407 differential proteins and 344 differential metabolites in the BMS with cognitive impairment (BC) group compared to the BMS with noncognitive impairment (BnC) group. Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis of combined proteomics and metabolomics data revealed the involvement of the arachidonic acid metabolic pathway and salivary secretion pathway in BMS and CI respectively.
Conclusion: Higher levels of depression and lower cognitive function appear to be more closely associated with BMS. The pathways of arachidonic acid metabolism and salivary secretion may play significant roles in the pathogenesis of BMS and CI respectively.
期刊介绍：
Journal of Oral Rehabilitation aims to be the most prestigious journal of dental research within all aspects of oral rehabilitation and applied oral physiology. It covers all diagnostic and clinical management aspects necessary to re-establish a subjective and objective harmonious oral function.
Oral rehabilitation may become necessary as a result of developmental or acquired disturbances in the orofacial region, orofacial traumas, or a variety of dental and oral diseases (primarily dental caries and periodontal diseases) and orofacial pain conditions. As such, oral rehabilitation in the twenty-first century is a matter of skilful diagnosis and minimal, appropriate intervention, the nature of which is intimately linked to a profound knowledge of oral physiology, oral biology, and dental and oral pathology.
The scientific content of the journal therefore strives to reflect the best of evidence-based clinical dentistry. Modern clinical management should be based on solid scientific evidence gathered about diagnostic procedures and the properties and efficacy of the chosen intervention (e.g. material science, biological, toxicological, pharmacological or psychological aspects). The content of the journal also reflects documentation of the possible side-effects of rehabilitation, and includes prognostic perspectives of the treatment modalities chosen.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
