The effects of liquid bleach ingestion on children's esophageal and gastric mucosa.

IF 2.4 3区 医学 Q3 GASTROENTEROLOGY & HEPATOLOGY
Paolo Quitadamo, Angelamaria di Lauri, Rossana Albano, Valentina Laudadio, Piergiorgio Gragnaniello, Maria G Puoti, Cristina Bucci, Sara Isoldi, Francesco Cirillo, Rossella Turco, Ludovica Carangelo, Mariano Caldore
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引用次数: 0

Abstract

Objectives: The ingestion of caustic substances is currently a significant health concern in pediatric age, being bleach products among the most commonly ingested. The management of children having ingested bleach is currently controversial since scientific data on their degree of toxicity toward the esophageal and gastric mucosa are currently very poor. Therefore, our study aims at comprehensively analyzing the effects of bleach ingestion in children as well as at evaluating patterns of ingestions, clinical symptom development, and endoscopic findings.

Methods: This prospective observational study was carried out between January 2017 and December 2023 at the Pediatric Department of Santobono Children's Hospital in Naples. Children aged 0-18 years admitted for bleach ingestion were enrolled.

Results: One hundred children with a mean age of 58.7 months were included in the study. Eighty-nine/100 (89%) children had ingested household bleaches (both chlorine- or peroxidase-based) while 11/100 (11%) had ingested homemade or industrial bleaches. The latter were significantly more likely to develop esophagogastric lesions, while children having ingested commercially available household bleaches did not report significant mucosal lesions.

Conclusions: Our data suggest that the toxicity of commercially available household bleaches on the gastrointestinal tract is very low. Therefore, digestive endoscopy is generally unnecessary in case of household bleach ingestion. Conversely, a timely endoscopic evaluation and close follow-up should be performed in children who ingest homemade or industrial bleaches.

食入漂白剂对儿童食管及胃粘膜的影响。
目的:腐蚀性物质的摄入是目前儿科年龄的一个重要的健康问题,是漂白剂产品中最常见的摄入。由于目前关于漂白剂对食管和胃粘膜毒性程度的科学数据非常缺乏,因此对摄入漂白剂的儿童的处理目前存在争议。因此,我们的研究旨在全面分析儿童摄入漂白剂的影响,以及评估摄入模式、临床症状发展和内窥镜检查结果。方法:这项前瞻性观察性研究于2017年1月至2023年12月在那不勒斯Santobono儿童医院儿科进行。0-18岁因误食漂白剂入院的儿童被纳入研究对象。结果:共纳入100例患儿,平均年龄58.7个月。89 /100(89%)儿童摄入家用漂白剂(含氯或过氧化物酶),11/100(11%)儿童摄入自制或工业漂白剂。后者明显更容易发生食管胃病变,而摄入市售家用漂白剂的儿童没有报告明显的粘膜病变。结论:我们的数据表明,市售家用漂白剂对胃肠道的毒性非常低。因此,在家用漂白剂摄入的情况下,消化内窥镜检查通常是不必要的。相反,对于摄入自制或工业漂白剂的儿童,应及时进行内窥镜评估和密切随访。
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来源期刊
CiteScore
5.30
自引率
13.80%
发文量
467
审稿时长
3-6 weeks
期刊介绍: ​The Journal of Pediatric Gastroenterology and Nutrition (JPGN) provides a forum for original papers and reviews dealing with pediatric gastroenterology and nutrition, including normal and abnormal functions of the alimentary tract and its associated organs, including the salivary glands, pancreas, gallbladder, and liver. Particular emphasis is on development and its relation to infant and childhood nutrition.
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