Effect of docetaxel administration on fluid dynamics in mice.

Fujita Medical Journal Pub Date : 2025-05-01 Epub Date: 2024-12-27 DOI:10.20407/fmj.2024-023
Ayana Mawaki, Masushi Kohta, Aya Yoshimura, Toshio Nakatani, Shizuko Nagao, Junko Sugama
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Abstract

Objectives: The taxane chemotherapeutic agent docetaxel has been used as a therapy for various cancers. Some patients receiving docetaxel develop serious problems with fluid retention, which leads to peripheral edema formation, reducing the patient's quality of life. This study investigated the effect of docetaxel administration on fluid dynamics in mice as a step toward developing advanced preventive measures in nursing.

Methods: Mice were administered 10 mg/kg/day of docetaxel intravenously for 5 days as the intervention group or with normal saline as the control group. To investigate fluid dynamics on day 5, the leakage of blood plasma, interstitial fluid volume, and fluid transportation capacity into lymph vessels were evaluated and compared between the two groups.

Results: The Miles assay with Evans Blue, an albumin-binding dye, revealed that leakage of blood plasma was significantly increased in the control group compared with the intervention group (p<0.01). Results of the interstitial fluid volume and fluid transportation capacity were similar between the two groups, but the fluid transportation capacity tended to be higher in the intervention group.

Conclusions: Docetaxel administration in our mouse model caused the leakage of blood plasma without proteins from the blood vessels into the interstitial tissues, which appeared at the initial stage of edema formation. This model might be useful for assessing the leakage of blood plasma and, subsequently, the development of preventive measures against edema formation.

多西他赛给药对小鼠流体动力学的影响。
目的:紫杉烷类化疗药物多西他赛已被用于多种癌症的治疗。一些接受多西他赛的患者出现严重的液体潴留问题,导致周围水肿形成,降低患者的生活质量。本研究探讨了多西他赛给药对小鼠流体动力学的影响,为制定先进的护理预防措施迈出了一步。方法:以多西紫杉醇10 mg/kg/d为干预组,以生理盐水为对照组,连续5 d静脉注射。观察第5天的流体动力学,比较两组大鼠血浆漏量、间质液量和淋巴管输液能力。结果:白蛋白结合染料Evans Blue的Miles实验显示,对照组血浆渗漏量较干预组明显增加(p结论:我们的小鼠模型多西他赛引起血浆无蛋白从血管渗漏到间质组织,出现在水肿形成的初始阶段。该模型可能有助于评估血浆渗漏,并随后制定预防水肿形成的措施。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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