The Crucial Role of Body Mass Index on Growth Hormone Stimulation Tests in Children: An Exploration of Potential Gender-Related Differences.

IF 1 4区医学 Q3 PEDIATRICS

Clinical Pediatrics Pub Date : 2025-05-04 DOI:10.1177/00099228251335861

Hasan Ari, Nur Berna Celik, Senay Savas-Erdeve, Semra Cetinkaya, Nursel Muratoglu Sahin

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Abstract

The aim of the study was to investigate whether there are any gender-related differences in growth hormone stimulation test (GHST) in prepubertal short children, with a particular emphasis on body mass index (BMI). Prepubertal patients who had two unprimed GHST using clonidine and L-dopa were included in this retrospective study. The anthropometrics and laboratory parameters were evaluated. Patients were categorized based on their peak growth hormone (GH) levels (GH <7 versus ≥7 ng/mL), stimulant agent, and gender. A total of 125 children (Male:Female = 75:50) were included. The mean age of the patients was 7.1 ± 3.0 years. lg-peak clonidine stimulated GH was associated with BMI standard deviation score (SDS) (β [95% CI] = 1.903 [1.665-2.140], P = .003) in females, and with IGF-SDS in males (β [95% CI] = 1.124 [0.910-1.339], P = .026). lg-peak L-dopa stimulated GH was associated with BMI SDS and IGF1-SDS (β [95% CI] = 1.327 [0.968-1.686], P = .009) in females. The blunted effect of BMI showed gender-related differences in the prepubertal pediatric patients.

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体重指数在儿童生长激素刺激试验中的关键作用：潜在性别相关差异的探索

本研究旨在探讨青春期前矮小儿童的生长激素刺激测试（GHST）是否存在性别差异，并特别强调体重指数（BMI）。本研究纳入了使用可乐定和左旋多巴的青春期前未启动GHST的患者。对人体测量和实验室参数进行了评估。根据女性生长激素（GH）峰值水平（GH P = 0.003）和男性IGF-SDS （β [95% CI] = 1.124 [0.910-1.339], P = 0.026）对患者进行分类。长峰左旋多巴刺激GH与女性BMI SDS和IGF1-SDS相关（β [95% CI] = 1.327 [0.968-1.686], P = 0.009）。BMI的钝化作用在青春期前儿童患者中存在性别差异。

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来源期刊

Clinical Pediatrics 医学-小儿科

CiteScore

2.10

自引率

6.20%

发文量

189

审稿时长

3-8 weeks

期刊介绍： Clinical Pediatrics (CLP) a peer-reviewed monthly journal, is a must read for the busy pediatrician. CLP contains state-of-the-art, accurate, concise and down-to earth information on practical, everyday child care topics whether they are clinical, scientific, behavioral, educational, or ethical.