Subjective memory complaints at age 90 + in relation to cognition and risk of incident dementia: The 90 + Study.

IF 4.6 2区医学 Q1 GERIATRICS & GERONTOLOGY

International psychogeriatrics Pub Date : 2025-05-07 DOI:10.1016/j.inpsyc.2025.100083

Zarui A Melikyan, Colette Aguirre, Zeinah Al-Darsani, Katherine A Colcord, Annlia Paganini-Hill, Sarah E Tomaszewski Farias, Luohua Jiang, Claudia H Kawas, María M Corrada

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引用次数: 0

Abstract

Background and aims: Associations of Subjective Memory Complaints (SMC) with cognition and future dementia are poorly understood in the oldest old (age 90 +), who have high incidence and prevalence of cognitive impairment. This study aims to (1) report SMC frequency, (2) assess cross-sectional associations between SMC and cognitive test scores, and (3) compare the abilities of SMC, Mini-mental state examination (MMSE), and cognitive diagnosis to predict dementia in the oldest old.

Method: The 90 + Study participants without baseline dementia and with baseline SMC, MMSE, at least one other cognitive test, and cognitive diagnosis were included in cross-sectional analysis. A subset of this group with follow-up cognitive diagnosis was included in longitudinal analysis. Cross-sectional association between SMC and cognitive test scores was explored using linear regression. Risk of incident dementia in relation to baseline SMC, MMSE, and cognitive diagnosis was explored using three Cox regression models. Concordance Index (C-index) was used to compare model performance.

Results: In 893 participants with average age 93 years (range 90-102), 43 % had SMC. Cross-sectionally, SMC were associated with lower scores on memory, language, executive function. After 3.5 years of follow-up (range 0.4-16), 325 of 789 participants developed dementia. SMC, compared with no SMC, was associated with twice the risk of incident dementia (HR=2.16, 95 %CI, 1.72-2.72; p < 0.01). SMC predicted incident dementia as well as MMSE (p = 0.12), but not as well as cognitive diagnosis (p < 0.01).

Conclusions: Single SMC question might be useful to identify oldest old with cognitive impairment or at risk of dementia.

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90岁以上老年人主观记忆抱怨与认知和痴呆风险的关系：90岁以上老年人研究

背景和目的：主观记忆抱怨（SMC）与认知和未来痴呆的关系在老年人（90岁以上）中知之甚少，他们是认知障碍的高发和流行人群。本研究旨在(1)报道SMC频率，(2)评估SMC与认知测试分数的横断面相关性，(3)比较SMC、迷你精神状态检查（MMSE）和认知诊断预测老年痴呆的能力。方法：90 +无基线痴呆，基线SMC， MMSE，至少一项其他认知测试和认知诊断的研究参与者纳入横断面分析。随访认知诊断的这一组的一个子集被纳入纵向分析。采用线性回归探讨SMC与认知测试成绩的横断面关联。使用三种Cox回归模型探讨痴呆发生风险与基线SMC、MMSE和认知诊断的关系。采用一致性指数（C-index）比较模型的性能。结果：在893名平均年龄93岁（范围90-102）的参与者中，43%患有SMC。横断面上，SMC与记忆、语言、执行功能得分较低相关。经过3.5年的随访（范围0.4-16），789名参与者中有325人患上了痴呆症。与无SMC相比，SMC与痴呆发生风险的两倍相关(HR=2.16, 95% CI, 1.72-2.72；结论：单个SMC问题可能有助于识别有认知障碍或有痴呆风险的老年人。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International psychogeriatrics 医学-精神病学

CiteScore

9.10

自引率

8.60%

发文量

217

审稿时长

3-6 weeks

期刊介绍： A highly respected, multidisciplinary journal, International Psychogeriatrics publishes high quality original research papers in the field of psychogeriatrics. The journal aims to be the leading peer reviewed journal dealing with all aspects of the mental health of older people throughout the world. Circulated to over 1,000 members of the International Psychogeriatric Association, International Psychogeriatrics also features important editorials, provocative debates, literature reviews, book reviews and letters to the editor.