{"title":"Synthesis of Rh-MOF/PVA-PVP nanofibers for skin cancer and infection inhibition.","authors":"Ali Altharawi, Taibah Aldakhil, Manal A Alossaimi","doi":"10.3389/fchem.2025.1575183","DOIUrl":null,"url":null,"abstract":"<p><p>Using electrospinning for nanofiber production, we can create unique materials with multiple applications in various industries, including medical bandages and wound dressings. One of the most important features of these materials and using the electrospinning technique, is the incorporation of compounds and metals into their structure. In this study, a new metal-organic framework (MOF) was synthesized from rhodium, a metal with significant biological potential, which was then used to produce new nanofibers using electrospinning technique, (Rh-MOF/PVA-PVP nanofiber) by mixing polyvinyl alcohol (PVA) and polyvinylpyrrolidone (PVP). The newly synthesized nanofiber was tested against common microbial skin pathogens and cancer cells, showing significant inhibition. Specifically, an IC<sub>50</sub> value of 19.45 μg/mL against cancer cells and MIC values ranging from 4 μg/mL to 64 μg/mL μg against skin pathogenic strains were observed. This notable inhibitory ability can be attributed to both physical characteristics (with specific surface area of 2,348 m<sup>2</sup>/g), and chemical factors, including the active compounds present in its rhodium (Rh) structure. The synthesized Rh-MOF/PVA-PVP nanofiber has the potential for use in developing bioactive bandages, and wound dressings.</p>","PeriodicalId":12421,"journal":{"name":"Frontiers in Chemistry","volume":"13 ","pages":"1575183"},"PeriodicalIF":3.8000,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12066281/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Frontiers in Chemistry","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.3389/fchem.2025.1575183","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
Using electrospinning for nanofiber production, we can create unique materials with multiple applications in various industries, including medical bandages and wound dressings. One of the most important features of these materials and using the electrospinning technique, is the incorporation of compounds and metals into their structure. In this study, a new metal-organic framework (MOF) was synthesized from rhodium, a metal with significant biological potential, which was then used to produce new nanofibers using electrospinning technique, (Rh-MOF/PVA-PVP nanofiber) by mixing polyvinyl alcohol (PVA) and polyvinylpyrrolidone (PVP). The newly synthesized nanofiber was tested against common microbial skin pathogens and cancer cells, showing significant inhibition. Specifically, an IC50 value of 19.45 μg/mL against cancer cells and MIC values ranging from 4 μg/mL to 64 μg/mL μg against skin pathogenic strains were observed. This notable inhibitory ability can be attributed to both physical characteristics (with specific surface area of 2,348 m2/g), and chemical factors, including the active compounds present in its rhodium (Rh) structure. The synthesized Rh-MOF/PVA-PVP nanofiber has the potential for use in developing bioactive bandages, and wound dressings.
期刊介绍：
Frontiers in Chemistry is a high visiblity and quality journal, publishing rigorously peer-reviewed research across the chemical sciences. Field Chief Editor Steve Suib at the University of Connecticut is supported by an outstanding Editorial Board of international researchers. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to academics, industry leaders and the public worldwide.
Chemistry is a branch of science that is linked to all other main fields of research. The omnipresence of Chemistry is apparent in our everyday lives from the electronic devices that we all use to communicate, to foods we eat, to our health and well-being, to the different forms of energy that we use. While there are many subtopics and specialties of Chemistry, the fundamental link in all these areas is how atoms, ions, and molecules come together and come apart in what some have come to call the “dance of life”.
All specialty sections of Frontiers in Chemistry are open-access with the goal of publishing outstanding research publications, review articles, commentaries, and ideas about various aspects of Chemistry. The past forms of publication often have specific subdisciplines, most commonly of analytical, inorganic, organic and physical chemistries, but these days those lines and boxes are quite blurry and the silos of those disciplines appear to be eroding. Chemistry is important to both fundamental and applied areas of research and manufacturing, and indeed the outlines of academic versus industrial research are also often artificial. Collaborative research across all specialty areas of Chemistry is highly encouraged and supported as we move forward. These are exciting times and the field of Chemistry is an important and significant contributor to our collective knowledge.
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