Correlation between serum thyroid hormone level and metabolic steatohepatitis: A retrospective study

IF 3.8 3区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY

Digestive and Liver Disease Pub Date : 2025-06-01 DOI:10.1016/j.dld.2025.03.006

Chun-Yan Yang , Wei Guan , Yan Liu , Peng Zhang

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Abstract

Background

Metabolic steatohepatitis (MASH) is a common liver disease, and its association with serum thyroid hormone levels is unclear. This study aimed to analyze the association between MASH and serum levels of thyroid hormones in patients with normal thyroid function.

Methods

638 non-alcoholic fatty liver disease patients hospitalized in our hospital from March 2021 to March 2024 were retrospectively selected and divided into MASH (n = 262) and non-MASH (n = 376) groups based on the diagnosis made by expert pathologists. The clinical data of the patients were collected, and multivariate logistic regression analysis was utilized to investigate the association between MASH and serum thyroid hormone levels.

Results

Serum levels of thyroid-stimulating hormone (TSH) and free triiodothyronine (FT3) in the MASH group were significantly higher compared to the non-MASH group, and serum free thyroxine (FT4) levels were lower than those in non-MASH group. The FT3/FT4 ratio in MASH group was higher than that in non-MASH group (P < 0.05). Logistic regression analysis showed that serum levels of TSH, FT3 and FT4 were independent influencing factors for MASH. The area under receiver operating characteristic (ROC) curve of TSH, FT3, FT4 and FT3/FT4 for predicting the occurrence of MASH were 0.944, 0.973, 0.753 and 0.959, respectively.

Conclusions

Elevated serum levels of TSH, FT3, and the FT3/FT4 ratio, along with decreased serum FT4 levels, were independently associated with an increased risk of MASH.

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血清甲状腺激素水平与代谢性脂肪性肝炎相关性的回顾性研究。

背景：代谢性脂肪性肝炎（MASH）是一种常见的肝脏疾病，其与血清甲状腺激素水平的关系尚不清楚。本研究旨在分析甲状腺功能正常患者MASH与血清甲状腺激素水平的关系。方法：回顾性选择我院2021年3月~ 2024年3月收治的非酒精性脂肪肝患者638例，根据病理专家诊断分为MASH组（262例）和非MASH组（376例）。收集患者的临床资料，采用多因素logistic回归分析，探讨MASH与血清甲状腺激素水平的关系。结果：MASH组血清促甲状腺激素（TSH）和游离三碘甲状腺原氨酸（FT3）水平显著高于非MASH组，血清游离甲状腺素（FT4）水平显著低于非MASH组。MASH组FT3/FT4比值高于非MASH组（P < 0.05）。Logistic回归分析显示血清TSH、FT3、FT4水平是影响MASH的独立因素。TSH、FT3、FT4和FT3/FT4预测MASH发生的受试者工作特征（ROC）曲线下面积分别为0.944、0.973、0.753和0.959。结论：血清TSH、FT3和FT3/FT4比值升高以及血清FT4水平降低与MASH风险增加独立相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Digestive and Liver Disease 医学-胃肠肝病学

CiteScore

6.10

自引率

2.20%

发文量

632

审稿时长

19 days

期刊介绍： Digestive and Liver Disease is an international journal of Gastroenterology and Hepatology. It is the official journal of Italian Association for the Study of the Liver (AISF); Italian Association for the Study of the Pancreas (AISP); Italian Association for Digestive Endoscopy (SIED); Italian Association for Hospital Gastroenterologists and Digestive Endoscopists (AIGO); Italian Society of Gastroenterology (SIGE); Italian Society of Pediatric Gastroenterology and Hepatology (SIGENP) and Italian Group for the Study of Inflammatory Bowel Disease (IG-IBD). Digestive and Liver Disease publishes papers on basic and clinical research in the field of gastroenterology and hepatology. Contributions consist of: Original Papers Correspondence to the Editor Editorials, Reviews and Special Articles Progress Reports Image of the Month Congress Proceedings Symposia and Mini-symposia.