Analysis of a medication discrepancy management platform in reducing medication discrepancy and influencing factors among elderly patients with polypharmacy.

IF 2.4 3区医学 Q3 PHARMACOLOGY & PHARMACY

European Journal of Clinical Pharmacology Pub Date : 2025-04-17 DOI:10.1007/s00228-025-03831-9

Jingyan Song, Jie Huang, Jian Mao, Jing Cao, Qinghua Zhao

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引用次数: 0

Abstract

Objective: This study aimed to investigate the impact of a medication discrepancy management platform on reducing medication discrepancies among elderly patients with polypharmacy and to analyze influencing factors.

Methods: A total of 110 elderly polypharmacy patients were divided into a control group and an observation group using a random number method, each with 55 participants. The control group received routine management, while the observation group utilized a medication discrepancy management platform. Medication knowledge and adherence before and after intervention were compared between the two groups. Reasons and types of medication discrepancies were statistically analyzed. Patients were divided into a non-discrepancy group and a discrepancy group, with multivariate logistic regression used to analyze factors influencing medication discrepancies among elderly patients with polypharmacy.

Results: Utilizing a medication discrepancy management platform significantly improved medication knowledge and adherence among elderly patients (P < 0.05). A total of 34 patients (30.91%) experienced at least one medication discrepancy within one-week post-discharge, primarily involving decreased frequency, missed doses, reduction in medication types, and medication substitution. Multivariate logistic regression analysis showed that the use of the medication discrepancy management platform, caregiver involvement, and prescribed discharge medications (7-8 types or ≥ 9 types) were independent factors influencing medication discrepancies in elderly patients (P < 0.05).

Conclusion: Using a medication discrepancy management platform can effectively reduce medication discrepancies in elderly patients with polypharmacy and improve elderly patients' adherence to medication. Expanding the platform's use can enhance discharge guidance quality and ensure medication safety.

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用药差异管理平台降低老年多药患者用药差异及影响因素分析。

目的：探讨用药差异管理平台对减少老年多药患者用药差异的影响，并分析影响因素。方法：采用随机数字法将110例老年综合用药患者分为对照组和观察组，每组55人。对照组采用常规管理，观察组采用用药差异管理平台。比较两组患者干预前后的用药知识和依从性。统计分析用药差异的原因及类型。将患者分为无差异组和差异组，采用多因素logistic回归分析老年多重用药患者用药差异的影响因素。结果：使用用药差异管理平台可显著提高老年患者的用药知识和依从性（P < 0.05）。共有34例患者（30.91%）在出院后一周内至少出现一次用药差异，主要包括频率减少、漏给剂量、药物类型减少和药物替代。多因素logistic回归分析显示，使用用药差异管理平台、护理人员参与、出院处方药物（7-8种或≥9种）是影响老年患者用药差异的独立因素（P < 0.05）。结论：使用用药差异管理平台可有效减少老年多药患者的用药差异，提高老年患者的用药依从性。扩大平台的使用，可以提高出院指导质量，保证用药安全。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European Journal of Clinical Pharmacology 医学-药学

CiteScore

5.40

自引率

3.40%

发文量

170

审稿时长

3-8 weeks

期刊介绍： The European Journal of Clinical Pharmacology publishes original papers on all aspects of clinical pharmacology and drug therapy in humans. Manuscripts are welcomed on the following topics: therapeutic trials, pharmacokinetics/pharmacodynamics, pharmacogenetics, drug metabolism, adverse drug reactions, drug interactions, all aspects of drug development, development relating to teaching in clinical pharmacology, pharmacoepidemiology, and matters relating to the rational prescribing and safe use of drugs. Methodological contributions relevant to these topics are also welcomed. Data from animal experiments are accepted only in the context of original data in man reported in the same paper. EJCP will only consider manuscripts describing the frequency of allelic variants in different populations if this information is linked to functional data or new interesting variants. Highly relevant differences in frequency with a major impact in drug therapy for the respective population may be submitted as a letter to the editor. Straightforward phase I pharmacokinetic or pharmacodynamic studies as parts of new drug development will only be considered for publication if the paper involves -a compound that is interesting and new in some basic or fundamental way, or -methods that are original in some basic sense, or -a highly unexpected outcome, or -conclusions that are scientifically novel in some basic or fundamental sense.