Adverse effects and underlying mechanism of rare earth elements.

IF 5.3 2区 环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES
Xuemei Wang, Feiyu Wang, Lirong Yan, Zhixiang Gao, Shengbo Yang, Zhigang Su, Wenting Chen, Yanan Li, Fenghong Wang
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引用次数: 0

Abstract

Background: Rare earth elements (REEs) have found broad application in a range of industries, including electronics, automotive, agriculture, and healthcare. However, their widespread utilization and release into the environment pose potential risks of human exposure. Despite extensive research on REEs toxicity, the relationship between exposure and subsequent health concerns remains ambiguous. Given that the biological effects of REEs can vary based on their design and application, assessing their toxicity can be highly challenging.

Objective: This review is to offer a thorough comprehension of REEs' application and toxicity, guiding future research and policy-making to safeguard public health and environmental integrity.

Methods: A systematic search across PubMed, Web of Science, Cochrane Library, and Embase was conducted using the terms: ("rare earth" OR "lanthanoid") AND ("health hazard" OR "toxic" OR "adverse health effect"). From 5,924 initial records, 89 studies were selected through deduplication and two-stage screening to assess systemic toxicity of REEs. An additional 100 articles on REEs mechanisms and applications were incorporated via citation tracking. All selections followed PRISMA guidelines with dual-author verification to ensure rigor.

Conclusion: The review emphasizes REEs' applications in various domains and documents potential environmental pathways. Furthermore, it elaborates on current processes to assess REEs-related toxicity across different model organisms and cell lines, estimating health threats posed by REEs exposure. Finally, based on the findings of both in vivo and in vitro experiments, the potential toxic mechanisms of REEs are detailed. To guide future research and policy development to safeguard public health and environmental integrity.

稀土元素的不利影响及其作用机制。
背景:稀土元素(ree)在电子、汽车、农业和医疗保健等一系列行业中有着广泛的应用。然而,它们的广泛使用和释放到环境中构成了人类接触的潜在风险。尽管对稀土的毒性进行了广泛的研究,但接触稀土与随后的健康问题之间的关系仍然不明确。考虑到稀土元素的生物效应可能因其设计和应用而异,评估其毒性可能非常具有挑战性。目的:综述稀土元素的应用和毒性,指导未来的研究和政策制定,以维护公众健康和环境的完整性。方法:对PubMed、Web of Science、Cochrane Library和Embase进行系统检索,检索词为:(“稀土”或“类镧”)和(“健康危害”或“有毒”或“不良健康影响”)。通过重复数据删除和两阶段筛选,从5924份初始记录中选择了89份研究来评估稀土元素的全身毒性。通过引文跟踪纳入了另外100篇关于稀土元素机制和应用的文章。所有选择都遵循PRISMA指导方针,并经过双重作者验证,以确保严谨性。结论:本文强调了稀土元素在各个领域的应用,并揭示了其潜在的环境途径。此外,它详细说明了目前评估不同模式生物和细胞系中与稀土有关的毒性的过程,估计了稀土暴露造成的健康威胁。最后,根据体内和体外实验的结果,详细介绍了稀土的潜在毒性机制。指导未来的研究和政策制定,以保障公众健康和环境的完整性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Environmental Health
Environmental Health 环境科学-公共卫生、环境卫生与职业卫生
CiteScore
10.10
自引率
1.70%
发文量
115
审稿时长
3.0 months
期刊介绍: Environmental Health publishes manuscripts on all aspects of environmental and occupational medicine and related studies in toxicology and epidemiology. Environmental Health is aimed at scientists and practitioners in all areas of environmental science where human health and well-being are involved, either directly or indirectly. Environmental Health is a public health journal serving the public health community and scientists working on matters of public health interest and importance pertaining to the environment.
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