{"title":"Comparable Diagnostic Value of 99mTc-FAPI-46 SPECT/CT and 18F-FDG PET/CT in Cholangiocarcinoma: A Case Report.","authors":"Nasrin Raeisi, Amin Saber Tanha, Mitra Ghahraman, Kamran Aryana, Atena Aghaee","doi":"10.1097/RLU.0000000000005877","DOIUrl":null,"url":null,"abstract":"<p><p>We describe a 51-year-old man with cholangiocarcinoma of the common bile duct. Initially deemed nonmetastatic, he was a candidate for curative surgery and liver transplantation. However, during laparotomy, peritoneal seeding was discovered, necessitating omentectomy and lesion resection. Following chemotherapy, the patient underwent 18F-FDG PET/CT for re-staging, revealing uptake in the primary tumor and a right iliac bone metastasis. Subsequently, FAPI-based scintigraphy using 99mTc-FAPI-46 as a novel conventional imaging agent demonstrated comparable uptake in both lesions. This case highlights the diagnostic potential of 99mTc-FAPI-46 SPECT/CT as an alternative to 18F-FDG PET/CT and 68Ga-FAPI in cholangiocarcinoma, particularly in resource-limited settings.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":""},"PeriodicalIF":9.6000,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical Nuclear Medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1097/RLU.0000000000005877","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}
引用次数: 0
Abstract
We describe a 51-year-old man with cholangiocarcinoma of the common bile duct. Initially deemed nonmetastatic, he was a candidate for curative surgery and liver transplantation. However, during laparotomy, peritoneal seeding was discovered, necessitating omentectomy and lesion resection. Following chemotherapy, the patient underwent 18F-FDG PET/CT for re-staging, revealing uptake in the primary tumor and a right iliac bone metastasis. Subsequently, FAPI-based scintigraphy using 99mTc-FAPI-46 as a novel conventional imaging agent demonstrated comparable uptake in both lesions. This case highlights the diagnostic potential of 99mTc-FAPI-46 SPECT/CT as an alternative to 18F-FDG PET/CT and 68Ga-FAPI in cholangiocarcinoma, particularly in resource-limited settings.
期刊介绍：
Clinical Nuclear Medicine is a comprehensive and current resource for professionals in the field of nuclear medicine. It caters to both generalists and specialists, offering valuable insights on how to effectively apply nuclear medicine techniques in various clinical scenarios. With a focus on timely dissemination of information, this journal covers the latest developments that impact all aspects of the specialty.
Geared towards practitioners, Clinical Nuclear Medicine is the ultimate practice-oriented publication in the field of nuclear imaging. Its informative articles are complemented by numerous illustrations that demonstrate how physicians can seamlessly integrate the knowledge gained into their everyday practice.
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