Progress on the mechanism of intestinal microbiota against colorectal cancer.

IF 4.6 2区医学 Q2 IMMUNOLOGY

Frontiers in Cellular and Infection Microbiology Pub Date : 2025-04-28 eCollection Date: 2025-01-01 DOI:10.3389/fcimb.2025.1565103

Guoqiang Xing, Yu Cui, Zhiyue Guo, Bing Han, Guogang Zhao

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Abstract

The intestinal microbiota plays a crucial role in the occurrence and development of colorectal cancer, and its anti - colorectal cancer mechanism has become a research hotspot. This article comprehensively expounds on the molecular mechanisms of the intestinal microbiota in anti - colorectal cancer, including aspects such as immune regulation, activation of carcinogenic signaling pathways (it should be noted that it is more reasonable to be "inhibition of carcinogenic signaling pathways"), metabolite - mediated effects, and maintenance of intestinal barrier function. At the same time, it explores the roles and potential mechanisms of intervention methods such as probiotic supplementation therapy, immunotherapy, and fecal microbiota transplantation. In addition, it analyzes the impact of the intestinal flora on the therapeutic efficacy of colorectal cancer. The existing research results are summarized, and the future research directions are prospected, with the aim of providing new theoretical bases and treatment ideas for the prevention and treatment of colorectal cancer.

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肠道菌群抗结直肠癌机制研究进展。

肠道菌群在结直肠癌的发生发展中起着至关重要的作用，其抗结直肠癌的机制已成为研究热点。本文全面阐述了肠道微生物群在抗结直肠癌中的分子机制，包括免疫调节、致癌信号通路的激活（需要注意的是“抑制致癌信号通路”更合理）、代谢物介导的作用、肠道屏障功能的维持等方面。同时探讨益生菌补充疗法、免疫疗法、粪便菌群移植等干预方法的作用和潜在机制。此外，还分析了肠道菌群对结直肠癌治疗效果的影响。对现有的研究成果进行总结，并对未来的研究方向进行展望，以期为结直肠癌的防治提供新的理论依据和治疗思路。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in Cellular and Infection Microbiology IMMUNOLOGY-MICROBIOLOGY

CiteScore

7.90

自引率

7.00%

发文量

1817

审稿时长

14 weeks

期刊介绍： Frontiers in Cellular and Infection Microbiology is a leading specialty journal, publishing rigorously peer-reviewed research across all pathogenic microorganisms and their interaction with their hosts. Chief Editor Yousef Abu Kwaik, University of Louisville is supported by an outstanding Editorial Board of international experts. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide. Frontiers in Cellular and Infection Microbiology includes research on bacteria, fungi, parasites, viruses, endosymbionts, prions and all microbial pathogens as well as the microbiota and its effect on health and disease in various hosts. The research approaches include molecular microbiology, cellular microbiology, gene regulation, proteomics, signal transduction, pathogenic evolution, genomics, structural biology, and virulence factors as well as model hosts. Areas of research to counteract infectious agents by the host include the host innate and adaptive immune responses as well as metabolic restrictions to various pathogenic microorganisms, vaccine design and development against various pathogenic microorganisms, and the mechanisms of antibiotic resistance and its countermeasures.