Pruritus and Fatigue in Patients With Metabolic Dysfunction-Associated Steatotic Liver Disease: A Study of Turkish Patients From the Global NASH/MASH Registry.

IF 3 3区医学 Q2 GASTROENTEROLOGY & HEPATOLOGY

Clinical and Translational Gastroenterology Pub Date : 2025-04-28 DOI:10.14309/ctg.0000000000000844

Yusuf Yilmaz, Caglayan Keklikkiran, Andrei Racila, Maria Stepanova, Zobair M Younossi

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引用次数: 0

Abstract

Introduction: Despite being underappreciated, pruritus and fatigue are not uncommon in metabolic dysfunction-associated steatotic liver disease (MASLD). In this prospective registry-based study, we sought to evaluate the prevalence, predictors, and impact of these symptoms on patient-reported outcomes (PROs) in patients with MASLD from Türkiye, a country with one of the highest burdens of MASLD globally.

Methods: A total of 1,874 Turkish patients from the Global Liver Registry were included. Significant pruritus and fatigue were defined using the Chronic Liver Disease Questionnaire-nonalcoholic steatohepatitis and the Functional Assessment of Chronic Illness Therapy-Fatigue, respectively. PROs were assessed using the Chronic Liver Disease Questionnaire-nonalcoholic steatohepatitis, Functional Assessment of Chronic Illness Therapy-Fatigue, and the Work Productivity and Activity Impairment: Specific Health Problem questionnaire.

Results: The prevalence of significant pruritus and fatigue was 37% and 33%, respectively. Both symptoms were significantly associated with female sex, type 2 diabetes, depression, abdominal pain, and lack of regular exercise. Patients with these symptoms had significantly worse PROs, with impairments up to 31% (all P < 0.0001). Over 1-2 years, symptoms persisted in 47%-52% of patients with baseline pruritus and 33%-39% with baseline fatigue. Independent predictors of a higher likelihood of resolution of pruritus included the absence of fatigue at baseline and the lack of abdominal pain, with odds ratios of 0.36 (95% confidence interval: 0.22-0.59) and 0.60 (95% confidence interval: 0.39-0.91), respectively (both P < 0.05).

Discussion: Pruritus and fatigue are common in MASLD, significantly impairing PROs and often persisting over time. Regular assessment and management are essential to improve patients' well-being and functioning.

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代谢功能障碍相关脂肪变性肝病患者的瘙痒和疲劳：一项来自全球NASH/MASH登记处的土耳其患者研究

背景和目的：瘙痒和疲劳在代谢功能障碍相关的脂肪变性肝病（MASLD）中并不罕见，尽管未被充分认识。在这项基于登记的前瞻性研究中，我们试图评估来自斯里兰卡（全球MASLD负担最高的国家之一）的MASLD患者的患病率、预测因素以及这些症状对患者报告结局（PROs）的影响。方法：从全球肝脏登记处共纳入1874名土耳其患者。使用慢性肝病问卷- nash （CLDQ-NASH）和慢性疾病治疗-疲劳功能评估（FACIT-F）分别定义明显的瘙痒和疲劳。使用CLDQ-NASH、FACIT-F和工作效率和活动障碍：特定健康问题（WPAI:SHP）问卷对PROs进行评估。结果：明显瘙痒和疲劳的发生率分别为37%和33%。这两种症状都与女性、2型糖尿病、抑郁症、腹痛和缺乏定期运动显著相关。有这些症状的患者的PROs明显更差，损伤高达31%（均p < 0.0001）。在1-2年的时间里，47-52%的基线瘙痒患者和33-39%的基线疲劳患者症状持续。瘙痒缓解可能性较高的独立预测因子包括基线时无疲劳和无腹痛，比值比分别为0.36（95%可信区间[CI]: 0.22-0.59）和0.60 (95% CI: 0.39-0.91)（均p < 0.05）。结论：瘙痒和疲劳在MASLD中很常见，明显损害PROs，并且经常持续一段时间。定期评估和管理对于改善患者的健康和功能至关重要。

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来源期刊

Clinical and Translational Gastroenterology GASTROENTEROLOGY & HEPATOLOGY-

CiteScore

7.00

自引率

0.00%

发文量

114

审稿时长

16 weeks

期刊介绍： Clinical and Translational Gastroenterology (CTG), published on behalf of the American College of Gastroenterology (ACG), is a peer-reviewed open access online journal dedicated to innovative clinical work in the field of gastroenterology and hepatology. CTG hopes to fulfill an unmet need for clinicians and scientists by welcoming novel cohort studies, early-phase clinical trials, qualitative and quantitative epidemiologic research, hypothesis-generating research, studies of novel mechanisms and methodologies including public health interventions, and integration of approaches across organs and disciplines. CTG also welcomes hypothesis-generating small studies, methods papers, and translational research with clear applications to human physiology or disease. Colon and small bowel Endoscopy and novel diagnostics Esophagus Functional GI disorders Immunology of the GI tract Microbiology of the GI tract Inflammatory bowel disease Pancreas and biliary tract Liver Pathology Pediatrics Preventative medicine Nutrition/obesity Stomach.