Associations of obesity defined comprehensively by body mass index and body fat percentage with osteopenia.

IF 2.2 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

Clinics Pub Date : 2025-05-08 eCollection Date: 2025-01-01 DOI:10.1016/j.clinsp.2025.100674

Xin Liu, Yan Lou, Zhiyong Chang, Changyuan Gu, Bin Du, Guangquan Sun

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引用次数: 0

Abstract

Objective: To explore the association of obesity comprehensively defined by Body Mass Index (BMI) and Body Fat percentage (BF%) with osteopenia.

Methods: In this cross-sectional study, data of adult men and postmenopausal women aged ≥ 50 years old were obtained from the National Health and Nutrition Examination Surveys (NHANES) database. Weighted logistic regression analysis was conducted to investigate the association of BF% obesity with osteopenia in participants who had different gender and BMI obesity conditions. The association of obesity comprehensively evaluated by BMI and BF% with osteopenia was also explored in the total population and in gender subgroups.

Results: Among 1720 eligible subjects, 1054 had osteopenia. Multivariate analysis suggested that in males, BMI obesity combined with BF% obesity was associated with higher osteopenia odds compared to BMI obesity only (Odds Ratio [OR = 4.01], 95% Confidence Interval [95% CI 1.43‒11.27]). Compared to participants with both BMI and BF% obesity, those with BMI obesity have lower osteopenia odds (OR = 0.46, 95% CI 0.28‒0.76), whereas those with BF% obesity have higher odds of osteopenia (OR = 2.03, 95% CI 1.35‒3.05, p = 0.002). In females, compared to BMI obesity combined with BF% obesity, BF% obesity (OR = 3.37, 95% CI 1.47‒7.73) or non-obesity (OR = 2.11, 95% CI 1.18‒3.75) was respectively associated with higher osteopenia odds. In males, BMI obesity was linked to lower osteopenia odds compared to both BMI and BF% obesity (OR = 0.25, 95% CI 0.10‒0.62).

Conclusions: The comprehensively assessed obesity by BMI and BF% may be more meaningful in the evaluation of potential osteopenia risk, as well as further prevention and intervention of osteoporosis.

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体重指数和体脂率综合定义的肥胖与骨质减少的关系。

目的：探讨体重指数（BMI）和体脂率（BF%）综合定义的肥胖与骨质减少的关系。方法：在这项横断面研究中，年龄≥50岁的成年男性和绝经后女性的数据来自国家健康和营养检查调查（NHANES）数据库。采用加权logistic回归分析来调查不同性别和BMI肥胖状况的参与者中BF%肥胖与骨质减少的关系。通过BMI和BF%综合评价的肥胖与骨质减少的关系也在总人口和性别亚组中进行了探讨。结果：在1720名符合条件的受试者中，1054名患有骨质减少症。多因素分析表明，在男性中，BMI肥胖合并BF%肥胖与骨质减少的几率比仅BMI肥胖高（优势比[OR = 4.01]， 95%可信区间[95% CI 1.43-11.27]）。与BMI和BF%肥胖的参与者相比，BMI肥胖者骨质减少的几率较低（OR = 0.46, 95% CI 0.28-0.76），而BF%肥胖者骨质减少的几率较高（OR = 2.03, 95% CI 1.35-3.05, p = 0.002）。在女性中，与BMI肥胖合并BF%肥胖相比，BF%肥胖（OR = 3.37, 95% CI 1.47-7.73）或非肥胖（OR = 2.11, 95% CI 1.18-3.75）分别与较高的骨质减少率相关。在男性中，与BMI和BF%肥胖相比，BMI肥胖与骨质减少的几率较低相关（OR = 0.25, 95% CI 0.10-0.62）。结论：BMI和BF%综合评价肥胖对潜在骨质减少风险的评价，以及骨质疏松的进一步预防和干预可能更有意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinics 医学-医学：内科

CiteScore

4.10

自引率

3.70%

发文量

129

审稿时长

52 days

期刊介绍： CLINICS is an electronic journal that publishes peer-reviewed articles in continuous flow, of interest to clinicians and researchers in the medical sciences. CLINICS complies with the policies of funding agencies which request or require deposition of the published articles that they fund into publicly available databases. CLINICS supports the position of the International Committee of Medical Journal Editors (ICMJE) on trial registration.