Non-invasive and quantitative evaluation of myocardial PET imaging: Next step for advanced therapy.

IF 2.5 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Journal of cardiology Pub Date : 2025-04-08 DOI:10.1016/j.jjcc.2025.04.001

Atsushi Yamamoto, Michinobu Nagao, Kenji Fukushima, Junichi Yamaguchi

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引用次数: 0

Abstract

Myocardial positron emission tomography (PET) is superior in detecting ischemia in patients with left main or multivessel disease, conditions that are challenging to assess using single-photon emission computed tomography (SPECT). Additionally, quantitative measurements of myocardial blood flow and myocardial flow reserve (MFR) have been established as significant prognostic indicators for patients with ischemic heart disease. Moreover, ¹³N-ammonia PET offers high temporal and spatial resolution, enabling the assessment of both left and right ventricular strain, a quantitative marker of regional myocardial wall motion. Ongoing research aims to translate these advanced PET-based methodologies into SPECT imaging. Furthermore, MFR has proven valuable for diagnosing and predicting cardiac allograft vasculopathy in heart transplant recipients. More recently, it has also been utilized to evaluate the efficacy of cardiac regeneration therapy in individuals with severe heart failure and reduced cardiac function. This review presents existing evidence and highlights recent advancements in myocardial PET.

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心肌PET成像的无创和定量评估：高级治疗的下一步。

心肌正电子发射断层扫描（PET）在检测左主血管或多血管疾病患者的缺血方面具有优势，而单光子发射计算机断层扫描（SPECT）对这些疾病的评估具有挑战性。此外，心肌血流和心肌血流储备（MFR）的定量测量已被确立为缺血性心脏病患者预后的重要指标。此外，13n -氨PET具有较高的时间和空间分辨率，可以评估左心室和右心室应变，这是局部心肌壁运动的定量标志。正在进行的研究旨在将这些先进的基于pet的方法转化为SPECT成像。此外，MFR已被证明对心脏移植受者的异体移植血管病变有诊断和预测价值。最近，它也被用于评估心脏再生治疗对严重心力衰竭和心功能降低的个体的疗效。这篇综述介绍了现有的证据，并强调了心肌PET的最新进展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of cardiology CARDIAC & CARDIOVASCULAR SYSTEMS-

CiteScore

4.90

自引率

8.00%

发文量

202

审稿时长

29 days

期刊介绍： The official journal of the Japanese College of Cardiology is an international, English language, peer-reviewed journal publishing the latest findings in cardiovascular medicine. Journal of Cardiology (JC) aims to publish the highest-quality material covering original basic and clinical research on all aspects of cardiovascular disease. Topics covered include ischemic heart disease, cardiomyopathy, valvular heart disease, vascular disease, hypertension, arrhythmia, congenital heart disease, pharmacological and non-pharmacological treatment, new diagnostic techniques, and cardiovascular imaging. JC also publishes a selection of review articles, clinical trials, short communications, and important messages and letters to the editor.