Causal relationship between inflammatory cytokines and posttraumatic stress disorder: a Mendelian randomization study and potential mechanism analysis.

IF 4.1 2区医学 Q1 PSYCHIATRY

European Journal of Psychotraumatology Pub Date : 2025-12-01 Epub Date: 2025-05-02 DOI:10.1080/20008066.2025.2494480

Yingchong Li, Bangliang Xu, Zhitao Chen

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Abstract

Background: Post-traumatic stress disorder (PTSD) is a complex condition linked to inflammation. The causality between inflammatory cytokines and PTSD risk remains unclear.Methods: We conducted a bidirectional two-sample Mendelian randomization (MR) study using genome-wide association study (GWAS) data from 41 inflammatory cytokines and PTSD. Additional analyses included differential gene expression, protein-protein interaction, and functional enrichment to explore underlying mechanisms.Results: MR analysis indicated that higher levels of stem cell factor (SCF) and interleukin-4 (IL-4) are associated with a reduced risk of PTSD. Genes POGZ and LRIG2 were identified as mediators, implicated in the TGF-beta signalling pathway.Conclusion: Our findings suggest a protective role of certain cytokines against PTSD and highlight potential molecular mediators. This knowledge could inform future therapeutic strategies for PTSD.

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炎症细胞因子与创伤后应激障碍的因果关系：孟德尔随机研究和潜在机制分析。

背景：创伤后应激障碍（PTSD）是一种与炎症有关的复杂疾病。炎症细胞因子与PTSD风险之间的因果关系尚不清楚。方法：利用41种炎症因子与创伤后应激障碍的全基因组关联研究（GWAS）数据，进行了一项双向双样本孟德尔随机化（MR）研究。其他分析包括差异基因表达、蛋白蛋白相互作用和功能富集，以探索潜在的机制。结果：磁共振分析表明，较高水平的干细胞因子（SCF）和白细胞介素-4 （IL-4）与PTSD风险降低有关。基因POGZ和LRIG2被鉴定为介导tgf - β信号通路。结论：我们的研究结果提示了某些细胞因子对PTSD的保护作用，并强调了潜在的分子介质。这一知识可以为创伤后应激障碍的未来治疗策略提供信息。

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来源期刊

European Journal of Psychotraumatology Multiple-

CiteScore

7.60

自引率

12.00%

发文量

153

审稿时长

18 weeks

期刊介绍： The European Journal of Psychotraumatology (EJPT) is a peer-reviewed open access interdisciplinary journal owned by the European Society of Traumatic Stress Studies (ESTSS). The European Journal of Psychotraumatology (EJPT) aims to engage scholars, clinicians and researchers in the vital issues of how to understand, prevent and treat the consequences of stress and trauma, including but not limited to, posttraumatic stress disorder (PTSD), depressive disorders, substance abuse, burnout, and neurobiological or physical consequences, using the latest research or clinical experience in these areas. The journal shares ESTSS’ mission to advance and disseminate scientific knowledge about traumatic stress. Papers may address individual events, repeated or chronic (complex) trauma, large scale disasters, or violence. Being open access, the European Journal of Psychotraumatology is also evidence of ESTSS’ stand on free accessibility of research publications to a wider community via the web. The European Journal of Psychotraumatology seeks to attract contributions from academics and practitioners from diverse professional backgrounds, including, but not restricted to, those in mental health, social sciences, and health and welfare services. Contributions from outside Europe are welcome. The journal welcomes original basic and clinical research articles that consolidate and expand the theoretical and professional basis of the field of traumatic stress; Review articles including meta-analyses; short communications presenting new ideas or early-stage promising research; study protocols that describe proposed or ongoing research; case reports examining a single individual or event in a real‑life context; clinical practice papers sharing experience from the clinic; letters to the Editor debating articles already published in the Journal; inaugural Lectures; conference abstracts and book reviews. Both quantitative and qualitative research is welcome.