Prevalence of hepatitis B infection and its associated factors in rural South India.

IF 2 Q3 GASTROENTEROLOGY & HEPATOLOGY

Indian Journal of Gastroenterology Pub Date : 2025-04-24 DOI:10.1007/s12664-025-01768-6

Adhisakthi Rajalatchumi, Palanivel Chinnakali, Rahul Dhodapkar, Jeby Jose Olickal, Sadhana Subramanian, Sitanshu Sekhar Kar, Pazhanivel Mohan

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引用次数: 0

Abstract

Background: Information on the burden of hepatitis B infection is required for targeted interventions and streamlining the diagnosis and treatment facilities across various healthcare levels in India. Therefore, this study was aimed at determining the prevalence of hepatitis B infection and associated factors among the adult population in a rural area of South India.

Methods: A community-based cross-sectional study was conducted among the rural adult population aged 18 years and above between January 2021 and April 2022. Alere Determine^TM HBsAg rapid diagnostic test kit (RDT) was used to detect hepatitis B surface antigen (HBsAg) and a Chemiluminescent immunoassay (CLIA) test was used for confirmatory diagnosis. Data on the behavioral and clinical risk factors for HbsAg and other basic socio-demographic details were captured using a pre-tested, structured questionnaire.

Results: Total 5169 participants were included in the study. The mean (SD) age was 41 (15.7) years and 50% were males. About 20% reported alcohol use and 10% reported tobacco use. The prevalence of hepatitis B infection was 2.5% (95% CI = 2.05-2.91), of whom 10 (7.9%) had a known history of hepatitis B infection. Alcohol use (PR 2.8, 95% CI = 1.9 - 4.2), tobacco use (PR 2.8, 95% CI = 1.6-5.1), history of blood transfusion (PR 7.8, 95% CI = 4.7-13.0), history of dental procedures (PR 3.6, 95% CI = 2.5-5.1), tattoos (PR 3.5, 95% CI = 2.1-5.8) and having more than one sex partner (PR 6.8, 95% CI = 1.1-41.2) were significantly associated with hepatitis B infections.

Conclusion: Nearly three out of 100 individuals had hepatitis B infection in rural areas. Efforts to address hepatitis B transmission prevention holistically and with a public health approach must be enhanced.

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南印度农村乙型肝炎感染流行及其相关因素

背景：需要关于乙型肝炎感染负担的信息，以便进行有针对性的干预，并简化印度各级卫生保健机构的诊断和治疗设施。因此，本研究的目的是确定乙型肝炎感染的流行率和相关因素在印度南部农村地区的成人人口。方法：以社区为基础，于2021年1月至2022年4月对18岁及以上农村成年人口进行横断面研究。采用Alere DetermineTM HBsAg快速诊断试剂盒（RDT）检测乙型肝炎表面抗原（HBsAg），采用化学发光免疫分析法（CLIA）进行确诊。使用预先测试的结构化问卷获取HbsAg行为和临床风险因素以及其他基本社会人口学细节的数据。结果：共纳入5169名受试者。平均（SD）年龄41（15.7）岁，男性占50%。约20%的人报告使用酒精，10%的人报告使用烟草。乙型肝炎感染率为2.5% (95% CI = 2.05-2.91)，其中10人（7.9%）有已知的乙型肝炎感染史。饮酒（PR为2.8,95% CI = 1.9 - 4.2）、吸烟（PR为2.8,95% CI = 1.6-5.1）、输血史（PR为7.8,95% CI = 4.7-13.0）、牙科手术史（PR为3.6,95% CI = 2.5-5.1）、纹身（PR为3.5,95% CI = 2.1-5.8）和拥有不止一个性伴侣（PR为6.8,95% CI = 1.1-41.2）与乙型肝炎感染显著相关。结论：农村地区乙型肝炎感染率接近3 / 100。必须加强努力，以公共卫生方法全面解决乙型肝炎传播预防问题。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Indian Journal of Gastroenterology GASTROENTEROLOGY & HEPATOLOGY-

CiteScore

3.90

自引率

10.00%

发文量

期刊介绍： The Indian Journal of Gastroenterology aims to help doctors everywhere practise better medicine and to influence the debate on gastroenterology. To achieve these aims, we publish original scientific studies, state-of -the-art special articles, reports and papers commenting on the clinical, scientific and public health factors affecting aspects of gastroenterology. We shall be delighted to receive articles for publication in all of these categories and letters commenting on the contents of the Journal or on issues of interest to our readers.