Innovative surgical approaches for chronic rhinitis: nasal neurectomy mechanisms, techniques, and clinical outcomes.

IF 3.9 3区医学 Q2 IMMUNOLOGY

Expert Review of Clinical Immunology Pub Date : 2025-05-04 DOI:10.1080/1744666X.2025.2500610

Zengxiao Zhang, Hongzheng Wei, Chengshuo Wang, Luo Zhang, Yuan Zhang

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引用次数: 0

Abstract

Introduction: Chronic rhinitis (CR) represents a prevalent, persistent inflammatory condition of the nasal mucosa, substantially impacting patients' quality of life. Despite standard pharmacotherapy, many patients with refractory symptoms do not achieve adequate relief, highlighting the need for alternative interventions such as nasal neurectomy.

Areas covered: Literature was reviewed on the PubMed, EMBASE, and Web of Science databases published from March 1961 to April 2025. Our review discusses the underlying mechanisms, surgical techniques, and clinical outcomes of different nasal neurectomy approaches, including vidian neurectomy, vidian-branch neurectomy, and anterior ethmoidal neurectomy, as well as recent advancements in endoscopic and minimally invasive methods.

Expert opinion: Nasal neurectomy presents a promising alternative for managing refractory CR by directly targeting the neuro-immune pathways that drive symptoms. Understanding the mechanisms, techniques, and clinical outcomes in nasal neurectomy will not only advance our insight into CR pathophysiology but also guide the development of refined, patient-specific surgical strategies for optimal outcomes.

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慢性鼻炎的创新手术方法：鼻神经切除术机制、技术和临床结果。

慢性鼻炎（Chronic rhinitis， CR）是一种普遍的、持续的鼻黏膜炎症，严重影响患者的生活质量。尽管标准的药物治疗，许多患者的难治性症状没有得到充分的缓解，强调需要替代干预措施，如鼻神经切除术。涵盖的领域：从1961年3月到2025年4月在PubMed、EMBASE和Web of Science数据库上发表的文献进行了综述。本文综述了鼻部神经切除术的基本机制、手术技术和临床结果，包括鼻部神经切除术、鼻部神经分支切除术和筛前神经切除术，以及内镜和微创方法的最新进展。专家意见：鼻神经切除术通过直接靶向驱动症状的神经免疫通路，为治疗难治性CR提供了一种有希望的替代方法。了解鼻神经切除术的机制、技术和临床结果不仅将促进我们对CR病理生理学的了解，而且还将指导制定精细的、针对患者的手术策略，以获得最佳结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Expert Review of Clinical Immunology IMMUNOLOGY-

CiteScore

7.60

自引率

2.30%

发文量

221

审稿时长

6-12 weeks

期刊介绍： Expert Review of Clinical Immunology (ISSN 1744-666X) provides expert analysis and commentary regarding the performance of new therapeutic and diagnostic modalities in clinical immunology. Members of the International Editorial Advisory Panel of Expert Review of Clinical Immunology are the forefront of their area of expertise. This panel works with our dedicated editorial team to identify the most important and topical review themes and the corresponding expert(s) most appropriate to provide commentary and analysis. All articles are subject to rigorous peer-review, and the finished reviews provide an essential contribution to decision-making in clinical immunology. Articles focus on the following key areas: • Therapeutic overviews of specific immunologic disorders highlighting optimal therapy and prospects for new medicines • Performance and benefits of newly approved therapeutic agents • New diagnostic approaches • Screening and patient stratification • Pharmacoeconomic studies • New therapeutic indications for existing therapies • Adverse effects, occurrence and reduction • Prospects for medicines in late-stage trials approaching regulatory approval • Novel treatment strategies • Epidemiological studies • Commentary and comparison of treatment guidelines Topics include infection and immunity, inflammation, host defense mechanisms, congenital and acquired immunodeficiencies, anaphylaxis and allergy, systemic immune diseases, organ-specific inflammatory diseases, transplantation immunology, endocrinology and diabetes, cancer immunology, neuroimmunology and hematological diseases.