Risk Factors for Type 2 Diabetes Mellitus Relapse in More Than 5-Year Follow-up After Sleeve Gastrectomy with Transit Bipartition.

IF 2.9 3区医学 Q1 SURGERY

Obesity Surgery Pub Date : 2025-06-01 Epub Date: 2025-05-13 DOI:10.1007/s11695-025-07906-5

Cüneyt Kırkıl, Mesut Yur, İlayda Aydın, Ahmet Bozdağ, Ahmet Aslan, Mehmet Fatih Ebiloğlu

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引用次数: 0

Abstract

Background: In some patients who achieved complete remission (CR) of type 2 diabetes mellitus (T2DM) after sleeve gastrectomy with transit bipartition (TB), T2DM relapses after a while. ABCD scoring predicts the likelihood of remission following TB. However, the factors affecting T2DM relapse are unknown.

Methods: The data of patients with CR after TB who were followed for more than 5 years was analyzed retrospectively.

Results: The median follow-up of 56 patients, 29 of whom were female (51.8%), was 71 months (range: 61 to 101). Eleven of 56 patients (19.6%) had relapse in T2DM. Patients with an ABCD score less than 4 had a significantly higher rate of relapse. Its sensitivity and specificity rates were 90.9% and 93.3%, respectively. Preoperative C-peptide level (OR 0.032 [CI 0.003-0.295], p = 0.002), LDL-cholesterol level (OR 1.025 [CI 1.005-1.045], p = 0.013), duration of T2DM (OR 1.553 [1.216-1.983], p < 0.001), ABCD score (OR 0.047 [0.006-0.361], p = 0.003), and FIB-4 index (OR 6.073 [1.496-24.656], p = 0.012) were risk factors.

Conclusions: Patients with longer durations of T2DM, higher LDL-cholesterol levels, lower C-peptide levels and ABCD scores, and worse liver fibrosis are at a higher risk of relapse after achieving initial CR of T2DM with TB.

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随访5年以上的套筒胃切除术后2型糖尿病复发的危险因素

背景：在一些2型糖尿病（T2DM）患者在套管胃切除术合并中转双隔（TB）后完全缓解（CR）， T2DM在一段时间后复发。ABCD评分预测结核病后缓解的可能性。然而，影响2型糖尿病复发的因素尚不清楚。方法：回顾性分析5年以上结核后CR患者的临床资料。结果：56例患者中位随访时间为71个月（61 ~ 101个月），其中女性29例（51.8%）。56例患者中有11例（19.6%）T2DM复发。ABCD评分低于4分的患者复发率明显较高。其敏感性为90.9%，特异性为93.3%。术前c -肽水平（OR 0.032 [CI 0.003-0.295], p = 0.002）、ldl -胆固醇水平（OR 1.025 [CI 1.005-1.045], p = 0.013）、T2DM病程（OR 1.553 [1.226 -1.983], p）结论：T2DM合并TB达到初始CR后，病程越长、ldl -胆固醇水平越高、c -肽水平和ABCD评分越低、肝纤维化越严重的患者复发风险越高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Obesity Surgery 医学-外科

CiteScore

5.80

自引率

24.10%

发文量

567

审稿时长

3-6 weeks

期刊介绍： Obesity Surgery is the official journal of the International Federation for the Surgery of Obesity and metabolic disorders (IFSO). A journal for bariatric/metabolic surgeons, Obesity Surgery provides an international, interdisciplinary forum for communicating the latest research, surgical and laparoscopic techniques, for treatment of massive obesity and metabolic disorders. Topics covered include original research, clinical reports, current status, guidelines, historical notes, invited commentaries, letters to the editor, medicolegal issues, meeting abstracts, modern surgery/technical innovations, new concepts, reviews, scholarly presentations and opinions. Obesity Surgery benefits surgeons performing obesity/metabolic surgery, general surgeons and surgical residents, endoscopists, anesthetists, support staff, nurses, dietitians, psychiatrists, psychologists, plastic surgeons, internists including endocrinologists and diabetologists, nutritional scientists, and those dealing with eating disorders.