Powassan and Eastern Equine Encephalitis Virus Seroprevalence in Endemic Areas, United States, 2019-2020.

IF 7.2 2区医学 Q1 IMMUNOLOGY

Emerging Infectious Diseases Pub Date : 2025-05-01 DOI:10.3201/eid3105.240893

Hannah Padda, Claire Y-H Huang, Kacie Grimm, Brad J Biggerstaff, Jeremy P Ledermann, Janae Raetz, Karen Boroughs, Eric C Mossel, Stacey W Martin, Jennifer A Lehman, Rebecca L Townsend, David Krysztof, Paula Saá, Emily T N Dinh, Mary Grace Stobierski, Brenda Esponda-Morrison, Karen Ann A Wolujewicz, Matthew Osborne, Catherine M Brown, Brandi Hopkins, Elizabeth K Schiffman, Alex Garvin, Xia Lee, Rebecca A Osborn, Ryan J Wozniak, Aaron C Brault, Sridhar V Basavaraju, Susan L Stramer, J Erin Staples, Carolyn V Gould

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引用次数: 0

Abstract

Powassan virus (POWV) and Eastern equine encephalitis virus (EEEV) are regionally endemic arboviruses in the United States that can cause neuroinvasive disease and death. Recent identification of EEEV transmission through organ transplantation and POWV transmission through blood transfusion have increased concerns about infection risk. After historically high numbers of cases of both viruses were reported in 2019, we conducted a seroprevalence survey using blood donation samples from selected endemic counties. Specimens were screened for virus-specific neutralizing antibodies, and population seroprevalence was estimated using weights calibrated to county population census data. For POWV, median county seroprevalence in 4 states was 0.84%, ranging from 0% (95% CI 0%-2.28%) to 11.5% (95% CI 0.82%-40.9%). EEEV infection was identified in a single county (estimated seroprevalence 1.62% [95% CI 0.04%-8.75%]). Although seroprevalence estimates in sampled areas were generally low, additional investigation of higher-prevalence areas could inform risk for transmission from asymptomatic blood and organ donors.

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2019-2020年美国流行地区波瓦桑和东部马脑炎病毒血清阳性率

波瓦桑病毒（POWV）和东部马脑炎病毒（EEEV）是美国的区域性地方性虫媒病毒，可导致神经侵入性疾病和死亡。最近发现的通过器官移植传播的eev和通过输血传播的POWV增加了对感染风险的关注。在2019年报告了两种病毒的历史高病例数之后，我们使用来自选定流行县的献血样本进行了血清阳性率调查。对标本进行病毒特异性中和抗体筛选，并使用根据县人口普查数据校准的权重估计人群血清阳性率。对于POWV， 4个州的中位县血清患病率为0.84%，范围从0% （95% CI 0%-2.28%）到11.5% （95% CI 0.82%-40.9%）。在一个县发现EEEV感染（估计血清患病率为1.62% [95% CI 0.04%-8.75%]）。虽然抽样地区的血清患病率估计值普遍较低，但对高患病率地区的进一步调查可为无症状献血者和器官献血者传播的风险提供信息。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Emerging Infectious Diseases 医学-传染病学

CiteScore

17.30

自引率

1.70%

发文量

505

审稿时长

1 months

期刊介绍： Emerging Infectious Diseases is a monthly open access journal published by the Centers for Disease Control and Prevention. The primary goal of this peer-reviewed journal is to advance the global recognition of both new and reemerging infectious diseases, while also enhancing our understanding of the underlying factors that contribute to disease emergence, prevention, and elimination. Targeted towards professionals in the field of infectious diseases and related sciences, the journal encourages diverse contributions from experts in academic research, industry, clinical practice, public health, as well as specialists in economics, social sciences, and other relevant disciplines. By fostering a collaborative approach, Emerging Infectious Diseases aims to facilitate interdisciplinary dialogue and address the multifaceted challenges posed by infectious diseases.