Clinical Profile and Vitamin D Status in Beta Thalassemia Major Children at a Tertiary Care Institute of Central India: A Cross-Sectional Study.

IF 0.7 4区 医学 Q3 MEDICINE, GENERAL & INTERNAL
Nigerian Journal of Clinical Practice Pub Date : 2025-01-01 Epub Date: 2025-03-17 DOI:10.4103/njcp.njcp_592_24
R M Meshram, M A Salodkar, S R Yesambare, S M Mohite, R B Gite, V R Rathod
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引用次数: 0

Abstract

Background: In India, the prevalence of beta thalassemia is 3.74%, and sixty to eighty percent of thalassemic children have vitamin D deficiency syndrome.

Aim: To estimate the prevalence of vitamin D deficiency and parathyroid levels in thalassemic children of Central India.

Methods: This cross-sectional study was conducted on 61 diagnosed beta thalassemic children of 2-12 years of age at the pediatric department of the tertiary care institute of Central India for six months by consecutive sampling method. Demographic, transfusion, and clinical data were collected. Serum Vitamin D levels were estimated by electrochemical-luminescence technology and serum parathyroid hormone was by immunoassay. Complete blood count, serum ferritin/calcium/phosphorous, and liver functions test were performed. Frequency, mean, standard deviation, and correlation of various variables were performed.

Results: Three-fourths of the participants were above 5 years of age and male to female ratio was 1.5:1. Most (88.5%) cases required blood transfusion every 3-4 weeks duration and 80.3% were receiving chelation therapy and all of them were on oral Deferasirox. About half of the participants had serum ferritin levels 1000-3000 ng/dl, and 27 (44.3%) had levels more than 3000- 5000 ng/dl. The total mean vitamin D and parathyroid hormone were 18.4 ± 9.9 ng/ml, and 13.1 ± 15.4 pg/ml respectively. The prevalence of low vitamin D was 63.9% and low parathyroid level in 21.3% of participants. Serum vitamin D level was inversely related to age, serum ferritin level, and transfusion frequency while directly related to serum calcium level.

Conclusion: The prevalence of vitamin D deficiency is 63.9% and low parathyroid hormone is 21.3%. Serum vitamin D has a negative correlation with increased age and increased serum ferritin levels.

印度中部三级保健研究所β地中海贫血主要儿童的临床概况和维生素D状况:一项横断面研究。
背景:在印度,β地中海贫血的患病率为3.74%,60%至80%的地中海贫血儿童患有维生素D缺乏症。目的:估计印度中部地中海贫血儿童维生素D缺乏症和甲状旁腺激素水平的患病率。方法:采用连续抽样方法,对61例在印度中部三级保健研究所儿科诊断为2-12岁的β地中海贫血儿童进行为期6个月的横断面研究。收集了人口统计、输血和临床数据。电化学发光法测定血清维生素D水平,免疫分析法测定血清甲状旁腺激素水平。全血细胞计数、血清铁蛋白/钙/磷、肝功能检查。对各变量进行频率、均值、标准差和相关性分析。结果:四分之三的参与者年龄在5岁以上,男女比例为1.5:1。88.5%的患者需要每3 ~ 4周输血一次,80.3%的患者接受螯合治疗,所有患者均口服去铁宁。大约一半的参与者血清铁蛋白水平为1000-3000 ng/dl, 27人(44.3%)的水平超过3000- 5000 ng/dl。维生素D和甲状旁腺激素的总平均值分别为18.4±9.9 ng/ml和13.1±15.4 pg/ml。低维生素D患病率为63.9%,甲状旁腺水平低的比例为21.3%。血清维生素D水平与年龄、血清铁蛋白水平、输血频率呈负相关,与血清钙水平直接相关。结论:维生素D缺乏症患病率为63.9%,甲状旁腺激素低患病率为21.3%。血清维生素D与年龄增长和血清铁蛋白水平升高呈负相关。
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来源期刊
Nigerian Journal of Clinical Practice
Nigerian Journal of Clinical Practice MEDICINE, GENERAL & INTERNAL-
CiteScore
1.40
自引率
0.00%
发文量
275
审稿时长
4-8 weeks
期刊介绍: The Nigerian Journal of Clinical Practice is a Monthly peer-reviewed international journal published by the Medical and Dental Consultants’ Association of Nigeria. The journal’s full text is available online at www.njcponline.com. The journal allows free access (Open Access) to its contents and permits authors to self-archive final accepted version of the articles on any OAI-compliant institutional / subject-based repository. The journal makes a token charge for submission, processing and publication of manuscripts including color reproduction of photographs.
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