Beyond Repigmentation-A Prospective Study of Patients With Stable Vitiligo Treated With Suction Blister Epidermal Grafting Plus Phototherapy.

IF 2.5 3区医学 Q2 DERMATOLOGY

Dermatologic Surgery Pub Date : 2025-05-07 DOI:10.1097/DSS.0000000000004678

Lu Yang, Yuehua Liu, Tao Wang

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Abstract

Background: Vitiligo is a common skin disorder that greatly impacts patients' appearance. The effects of grafting surgery combined with phototherapy on repigmentation and quality of life in patients with vitiligo remain underexplored.

Objective: To evaluate the effect of suction blister epidermal grafting (SBEG) combined with phototherapy on repigmentation and quality of life in patients with stable vitiligo.

Materials and methods: This prospective study included 42 skin lesions from 23 patients with stable vitiligo who underwent SBEG followed by postoperative phototherapy. Repigmentation rate, Dermatology Life Quality Index (DLQI), and Vitiligo-specific Quality-of-life Instrument (VitiQoL) scores were assessed at 3 and 6 months postoperation.

Results: The mean repigmentation rates at 3 and 6 months were 63.35% (±4.90) and 70.23% (±4.27), respectively. Lesions covered with terminal hair exhibited lower repigmentation rates compared to those without. Quality of life improved significantly, with DLQI scores decreasing from 7.37 to 4.06 at 6 months postsurgery (p = .0213). No significant correlation was found between DLQI or VitiQoL improvement rates and repigmentation rates.

Conclusion: SBEG combined with postoperative phototherapy effectively promotes repigmentation in stable vitiligo, particularly in areas without terminal hair. The procedure also enhances patient quality of life, although the relationship between repigmentation and quality of life requires further investigation.

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超越色素沉着-吸疱表皮移植加光疗治疗稳定型白癜风患者的前瞻性研究。

背景：白癜风是一种常见的皮肤病，严重影响患者的外观。移植手术联合光疗对白癜风患者色素沉着和生活质量的影响仍未得到充分探讨。目的：探讨吸式水疱表皮移植术（SBEG）联合光疗对稳定型白癜风患者皮肤色素沉着及生活质量的影响。材料和方法：这项前瞻性研究包括23例稳定性白癜风患者的42个皮肤病变，这些患者接受SBEG手术后进行术后光疗。术后3个月和6个月分别评估再色素沉着率、皮肤病生活质量指数（DLQI）和白癜风特异性生活质量仪器（VitiQoL）评分。结果：术后3个月和6个月平均色素沉着率分别为63.35%（±4.90）和70.23%（±4.27）。有终末毛覆盖的病变与无终末毛覆盖的病变相比，表现出较低的再色素沉着率。术后6个月DLQI评分由7.37降至4.06 （p = 0.0213）。DLQI或VitiQoL改善率与再色素沉着率之间无显著相关性。结论：SBEG联合术后光疗能有效促进稳定型白癜风患者，尤其是无终末发部位的色素沉着。该手术也提高了患者的生活质量，尽管重新着色与生活质量之间的关系需要进一步研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Dermatologic Surgery 医学-皮肤病学

CiteScore

3.10

自引率

16.70%

发文量

547

期刊介绍： Exclusively devoted to dermatologic surgery, the Dermatologic Surgery journal publishes the most clinically comprehensive and up-to-date information in its field. This unique monthly journal provides today’s most expansive and in-depth coverage of cosmetic and reconstructive skin surgery and skin cancer through peer-reviewed original articles, extensive illustrations, case reports, ongoing features, literature reviews and correspondence. The journal provides information on the latest scientific information for all types of dermatologic surgery including: -Ambulatory phlebectomy- Blepharoplasty- Body contouring- Chemical peels- Cryosurgery- Curettage and desiccation- Dermabrasion- Excision and closure- Flap Surgery- Grafting- Hair restoration surgery- Injectable neuromodulators- Laser surgery- Liposuction- Microdermabrasion- Microlipoinjection- Micropigmentation- Mohs micrographic surgery- Nail surgery- Phlebology- Sclerotherapy- Skin cancer surgery- Skin resurfacing- Soft-tissue fillers. Dermatologists, dermatologic surgeons, plastic surgeons, oculoplastic surgeons and facial plastic surgeons consider this a must-read publication for anyone in the field.