Late neurological improvement during hospitalization is a predicative factor for acute ischemic stroke.

IF 2.8 3区医学 Q2 MEDICINE, RESEARCH & EXPERIMENTAL

European Journal of Medical Research Pub Date : 2025-04-24 DOI:10.1186/s40001-025-02469-8

Huimin Zhao, Qinrong Xu, Peng Chen, Xiaojing Guo, Guanhui Wu

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引用次数: 0

Abstract

Purpose: This study aimed to investigate whether late neurological improvement (LNI) during hospitalization serves as a favorable prognostic indicator in patients with acute ischemic stroke (AIS) and to identify the predictors of LNI.

Methods: We retrospectively analyzed data from the Safe Implementation of Treatments in Stroke (SITS) registry at two stroke centers in Egypt. LNI was defined as the lack of early neurological improvement (ENI) within 24 h after admission, accompanied by neurological improvement within 7 days of hospitalization. Multivariate logistic regression was employed to analyze the factors influencing favorable prognosis (modified Rankin Scale score 0-2) and LNI.

Results: A total of 834 patients with AIS were included in this study, of which 130 (15.6%) exhibited LNI. Among these, 99 (76.2%) achieved favorable outcomes. Both ENI (OR = 6.756, 95% CI 3.355-13.603, P < 0.001) and LNI (OR = 5.760, 95% CI 3.146-10.545, P < 0.001) were independently associated with favorable prognosis after adjustment. Predictors of LNI in multivariable-adjusted logistic regression included younger age (OR = 0.973, 95% CI 0.957-0.990, P = 0.001), higher baseline National Institutes of Health Scale (NIHSS) score (OR = 1.196, 95% CI 1.146-1.248, P < 0.001), and rt-PA treatment (OR = 1.953, 95% CI 1.206-3.163, P = 0.006).

Conclusions: Approximately three-quarters of patients with LNI are expected to achieve good outcome. LNI was a favorable prognostic indicator in patients with AIS and younger age, higher baseline NIHSS score and rt-PA treatment predicted LNI.

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住院期间晚期神经系统改善是急性缺血性脑卒中的预测因素。

目的：本研究旨在探讨住院期间晚期神经系统改善（LNI）是否可作为急性缺血性脑卒中（AIS）患者预后的有利指标，并确定LNI的预测因素。方法：我们回顾性分析了埃及两个卒中中心卒中治疗安全实施（SITS）登记的数据。LNI定义为入院后24小时内缺乏早期神经系统改善（ENI），住院后7天内伴有神经系统改善。采用多因素logistic回归分析影响预后良好（改良Rankin量表评分0-2分）和LNI的因素。结果：本研究共纳入834例AIS患者，其中130例（15.6%）出现LNI。其中，99例（76.2%）获得了良好的结局。两个ENI （OR = 6.756, 95% CI 3.355-13.603， P）结论：大约四分之三的LNI患者有望获得良好的预后。对于年龄较小的AIS患者，LNI是一个有利的预后指标，较高的基线NIHSS评分和rt-PA治疗可预测LNI。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European Journal of Medical Research 医学-医学：研究与实验

CiteScore

3.20

自引率

0.00%

发文量

247

审稿时长

>12 weeks

期刊介绍： European Journal of Medical Research publishes translational and clinical research of international interest across all medical disciplines, enabling clinicians and other researchers to learn about developments and innovations within these disciplines and across the boundaries between disciplines. The journal publishes high quality research and reviews and aims to ensure that the results of all well-conducted research are published, regardless of their outcome.