Amir Hossein Rajabi, Samaneh Zafarabadi, Kimia Jazi, Maryam Moghbel Baerz, Omid Bahrami, Gelareh Azarinoush, Pardis Habibi, Negar Azami, Shahram Paydar
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引用次数: 0
Abstract
Objectives: This systematic review explored gene expression and DNA methylation patterns to identify key pathways and molecular targets associated with post-traumatic stress disorder (PTSD), particularly its war-related subtype.
Methods: A comprehensive search of PubMed, Scopus, and Web of Science was conducted using keywords related to PTSD, gene expression, and DNA methylation. Studies published between 2000 to 2024 involving adult military personnel with confirmed PTSD based on the Diagnostic and Statistical Manual of Mental Disorders-5 (DSM-5) criteria were included. Animal studies, psychological interventions, and pharmacological research were excluded. Only cross-sectional, case-control, or cohort studies utilizing blood, saliva, or brain tissue samples were considered. Data from 28 studies were extracted using a predefined framework, focusing on population characteristics, study design, and identified hub genes.
Results: Key findings revealed the upregulation of immune-related genes (e.g., CCL4, NF-κB) and hypomethylation of inflammation-related genes. Downregulation of neurodevelopmental genes, such as Brain-Derived Neurotropic Factor (BDNF) and Down syndrome cell adhesion molecule (DSCAM), highlighted disruptions in synaptic plasticity. The identified pathways suggested potential biomarkers and therapeutic targets for precision medicine approaches.
Conclusion: This review highlighted the role of gene expression alterations in war-related PTSD. The identified genes might serve as candidates for personalized therapies. Further research is required to validate these findings and develop targeted interventions.
目的：本系统综述探讨了创伤后应激障碍（PTSD）的基因表达和DNA甲基化模式，以确定与创伤后应激障碍（PTSD），特别是其战争相关亚型相关的关键途径和分子靶点。方法：综合检索PubMed、Scopus和Web of Science，使用与PTSD、基因表达和DNA甲基化相关的关键词。根据精神疾病诊断与统计手册-5 （DSM-5）的标准，2000年至2024年间发表的涉及确诊PTSD的成年军人的研究被纳入其中。排除了动物实验、心理干预和药理学研究。仅考虑使用血液、唾液或脑组织样本的横断面、病例对照或队列研究。使用预定义的框架提取了28项研究的数据，重点关注人群特征、研究设计和已确定的中心基因。结果：主要发现免疫相关基因（如CCL4、NF-κB）上调，炎症相关基因低甲基化。神经发育基因的下调，如脑源性神经营养因子（BDNF）和唐氏综合症细胞粘附分子（DSCAM），突出了突触可塑性的破坏。已确定的途径为精准医学方法提供了潜在的生物标志物和治疗靶点。结论：本综述强调了基因表达改变在战争相关PTSD中的作用。鉴定出的基因可能成为个性化治疗的候选基因。需要进一步的研究来验证这些发现并制定有针对性的干预措施。
期刊介绍：
BEAT: Bulletin of Emergency And Trauma is an international, peer-reviewed, quarterly journal coping with original research contributing to the field of emergency medicine and trauma. BEAT is the official journal of the Trauma Research Center (TRC) of Shiraz University of Medical Sciences (SUMS), Hungarian Trauma Society (HTS) and Lusitanian Association for Trauma and Emergency Surgery (ALTEC/LATES) aiming to be a publication of international repute that serves as a medium for dissemination and exchange of scientific knowledge in the emergency medicine and trauma. The aim of BEAT is to publish original research focusing on practicing and training of emergency medicine and trauma to publish peer-reviewed articles of current international interest in the form of original articles, brief communications, reviews, case reports, clinical images, and letters.
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