Integrating pulmonary function testing with cardiopulmonary exercise testing for enhanced stratification in hypertrophic cardiomyopathy.

IF 5.1 2区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS

Heart Pub Date : 2025-04-16 DOI:10.1136/heartjnl-2025-325737

Robin Willixhofer, Massimo Mapelli, Nikita Baracchini, Nicola Campana, Teresa Maria Capovilla, Alessandro Nava, Elisabetta Salvioni, Carlo Vignati, Jeness Campodonico, Filippo Maria Rubbo, Damiano Magrì, Beatrice Pezzuto, Irene Mattavelli, Arianna Galotta, Nicolò Capra, Carriere Cosimo, Irena Tavčar, Maddalena Rossi, Christian Cadeddu, Marco Merlo, Gianfranco Sinagra, Piergiuseppe Agostoni

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引用次数: 0

Abstract

Background: Cardiopulmonary exercise testing (CPET) is essential for assessing patients with hypertrophic cardiomyopathy (HCM), but the role of pulmonary function testing (PFT) in refining patient stratification remains underexplored. This study investigates the relationship between PFT and CPET parameters in patients with HCM.

Methods: In this prospective two-centre study, 102 clinically stable patients with HCM underwent PFT and CPET. Spearman's correlation and multiple linear regression were used to assess relationships between PFT (forced vital capacity (FVC) and forced expiratory volume in 1 s (FEV_₁)) and CPET variables, adjusting for confounders.

Results: Patients exhibited preserved lung function (mean FVC: 90.7%; FEV₁: 92.5%). Strong correlations were observed between PFT and CPET metrics, including peak VO_₂ (FVC: r=0.649, p<0.001; FEV_₁: r=0.691, p<0.001) and peak ventilation (FVC: r=0.682, p<0.001; FEV_₁: r=0.688, p<0.001). Regression analysis confirmed independent associations between PFT and CPET performance (all p<0.001).

Conclusion: PFT metrics strongly correlate with CPET parameters in HCM, suggesting that PFT could complement CPET for a more comprehensive assessment of exercise capacity and patient stratification.

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合并肺功能检查与心肺运动检查对肥厚性心肌病的分层加强。

背景：心肺运动试验（CPET）对于评估肥厚性心肌病（HCM）患者至关重要，但肺功能试验（PFT）在细化患者分层中的作用仍未得到充分探讨。本研究探讨HCM患者PFT和CPET参数之间的关系。方法：在这项前瞻性双中心研究中，102例临床稳定的HCM患者接受了PFT和CPET治疗。采用Spearman相关和多元线性回归来评估PFT（用力肺活量（FVC）和1 s用力呼气量（FEV 1））和CPET变量之间的关系，并对混杂因素进行调整。结果：患者肺功能保持正常(平均FVC: 90.7%；残:92.5%)。PFT和CPET指标之间存在很强的相关性，包括VO 2峰值（FVC: r=0.649, p₁：r=0.691, p₁：r=0.688）。结论：PFT指标与HCM的CPET参数有很强的相关性，表明PFT可以补充CPET，更全面地评估运动能力和患者分层。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Heart 医学-心血管系统

CiteScore

10.30

自引率

5.30%

发文量

320

审稿时长

3-6 weeks

期刊介绍： Heart is an international peer reviewed journal that keeps cardiologists up to date with important research advances in cardiovascular disease. New scientific developments are highlighted in editorials and put in context with concise review articles. There is one free Editor’s Choice article in each issue, with open access options available to authors for all articles. Education in Heart articles provide a comprehensive, continuously updated, cardiology curriculum.