{"title":"Radioresistance Mechanisms in Head and Neck Cancer.","authors":"Quoc Khanh Nguyen, Bon Seok Koo","doi":"10.21053/ceo.2025-00029","DOIUrl":null,"url":null,"abstract":"<p><p>Head and neck cancer (HNC) is not only one of the deadliest malignant tumors but also significantly impacts patient quality of life because of its proximity to numerous critical organs. Radiotherapy is commonly used to treat HNC due to its effectiveness in targeting cancer cells while sparing adjacent organs. However, the emergence of radioresistance severely limits the efficacy of radiotherapy, frequently leading to poor prognosis and treatment failure. Consequently, an enhanced understanding of the underlying mechanisms of radioresistance could facilitate the development of novel treatment strategies aimed at reducing recurrence rates and improving survival outcomes. In this review, we summarize the primary mechanisms implicated in radioresistance in HNC from both cancer cell-intrinsic and tumor microenvironment perspectives. Furthermore, we discuss currently available radiation-sensitizing approaches to overcome radioresistance in HNC.</p>","PeriodicalId":10318,"journal":{"name":"Clinical and Experimental Otorhinolaryngology","volume":" ","pages":"210-224"},"PeriodicalIF":3.4000,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12404286/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical and Experimental Otorhinolaryngology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.21053/ceo.2025-00029","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/4/23 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"OTORHINOLARYNGOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Head and neck cancer (HNC) is not only one of the deadliest malignant tumors but also significantly impacts patient quality of life because of its proximity to numerous critical organs. Radiotherapy is commonly used to treat HNC due to its effectiveness in targeting cancer cells while sparing adjacent organs. However, the emergence of radioresistance severely limits the efficacy of radiotherapy, frequently leading to poor prognosis and treatment failure. Consequently, an enhanced understanding of the underlying mechanisms of radioresistance could facilitate the development of novel treatment strategies aimed at reducing recurrence rates and improving survival outcomes. In this review, we summarize the primary mechanisms implicated in radioresistance in HNC from both cancer cell-intrinsic and tumor microenvironment perspectives. Furthermore, we discuss currently available radiation-sensitizing approaches to overcome radioresistance in HNC.
期刊介绍：
Clinical and Experimental Otorhinolaryngology (Clin Exp Otorhinolaryngol, CEO) is an international peer-reviewed journal on recent developments in diagnosis and treatment of otorhinolaryngology-head and neck surgery and dedicated to the advancement of patient care in ear, nose, throat, head, and neck disorders. This journal publishes original articles relating to both clinical and basic researches, reviews, and clinical trials, encompassing the whole topics of otorhinolaryngology-head and neck surgery.
CEO was first issued in 2008 and this journal is published in English four times (the last day of February, May, August, and November) per year by the Korean Society of Otorhinolaryngology-Head and Neck Surgery. The Journal aims at publishing evidence-based, scientifically written articles from different disciplines of otorhinolaryngology field.
The readership contains clinical/basic research into current practice in otorhinolaryngology, audiology, speech pathology, head and neck oncology, plastic and reconstructive surgery. The readers are otolaryngologists, head and neck surgeons and oncologists, audiologists, and speech pathologists.
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