{"title":"Radioresistance mechanism in head and neck cancer.","authors":"QuocKhanh Nguyen, Bon Seok Koo","doi":"10.21053/ceo.2025-00029","DOIUrl":null,"url":null,"abstract":"<p><p>Head and neck cancer (HNC) is not only one of the deadliest malignant tumors but also a major burden on patient quality of life due to its proximity to various organs at risk. Radiotherapy is a treatment option for HNC because of its ability to eliminate cancer cells while preserving the organs. However, the development of radioresistance has severely hindered its therapeutic efficacy, often resulting in poor prognosis and treatment failure. Therefore, a better understanding of the mechanisms of radioresistance can help develop new treatment strategies to reduce recurrence rates and improve survival outcomes. We have summarized the main mechanisms associated with radioresistance in HNC from the perspectives of cancer cells and the tumor microenvironment. Moreover, we explored the radiation-sensitizing options currently available to overcome radioresistance in HNC.</p>","PeriodicalId":10318,"journal":{"name":"Clinical and Experimental Otorhinolaryngology","volume":" ","pages":""},"PeriodicalIF":2.9000,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical and Experimental Otorhinolaryngology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.21053/ceo.2025-00029","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"OTORHINOLARYNGOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Head and neck cancer (HNC) is not only one of the deadliest malignant tumors but also a major burden on patient quality of life due to its proximity to various organs at risk. Radiotherapy is a treatment option for HNC because of its ability to eliminate cancer cells while preserving the organs. However, the development of radioresistance has severely hindered its therapeutic efficacy, often resulting in poor prognosis and treatment failure. Therefore, a better understanding of the mechanisms of radioresistance can help develop new treatment strategies to reduce recurrence rates and improve survival outcomes. We have summarized the main mechanisms associated with radioresistance in HNC from the perspectives of cancer cells and the tumor microenvironment. Moreover, we explored the radiation-sensitizing options currently available to overcome radioresistance in HNC.
期刊介绍：
Clinical and Experimental Otorhinolaryngology (Clin Exp Otorhinolaryngol, CEO) is an international peer-reviewed journal on recent developments in diagnosis and treatment of otorhinolaryngology-head and neck surgery and dedicated to the advancement of patient care in ear, nose, throat, head, and neck disorders. This journal publishes original articles relating to both clinical and basic researches, reviews, and clinical trials, encompassing the whole topics of otorhinolaryngology-head and neck surgery.
CEO was first issued in 2008 and this journal is published in English four times (the last day of February, May, August, and November) per year by the Korean Society of Otorhinolaryngology-Head and Neck Surgery. The Journal aims at publishing evidence-based, scientifically written articles from different disciplines of otorhinolaryngology field.
The readership contains clinical/basic research into current practice in otorhinolaryngology, audiology, speech pathology, head and neck oncology, plastic and reconstructive surgery. The readers are otolaryngologists, head and neck surgeons and oncologists, audiologists, and speech pathologists.
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