Physical function as assessed by the Liver Frailty Index remains stable over time in patients with hepatocellular carcinoma treated with locoregional therapies.

IF 3 3区医学 Q2 GASTROENTEROLOGY & HEPATOLOGY

Clinical and Translational Gastroenterology Pub Date : 2025-05-06 DOI:10.14309/ctg.0000000000000854

Madeleine D Hu, Sy Han Chiou, Molly Delk, Cynthia Fenton, Jennifer C Lai, Michael Li

引用次数: 0

Abstract

Background: It is unknown how frailty evolves over time in patients with hepatocellular carcinoma (HCC) who are treated with locoregional therapies (LRTs).

Methods: We conducted a retrospective study of LRT-treated HCC patients with Liver Frailty Index (LFI) assessments. Linear mixed effects modeling was used to assess the impact of time (modeled linearly per month) and other variables on LFI.

Results: Of 201 patients enrolled, median baseline LFI was 3.54. LFI did not change significantly over time from study entry (p=0.93).

Conclusions: In our study, LFI remained stable over time after LRT, suggesting that LRT is generally well-tolerated.

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肝衰弱指数评估的肝细胞癌患者的身体功能随着时间的推移保持稳定。

背景：目前尚不清楚接受局部治疗（LRTs）的肝细胞癌（HCC）患者的虚弱是如何随着时间的推移而演变的。方法：我们对肝衰竭指数（LFI）评估的肝细胞癌患者进行了一项回顾性研究。使用线性混合效应建模来评估时间（每月线性建模）和其他变量对LFI的影响。结果：在201例入组患者中，基线LFI中位数为3.54。从研究开始，LFI没有随时间发生显著变化（p=0.93）。结论：在我们的研究中，LFI在LRT后一段时间内保持稳定，表明LRT通常耐受良好。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical and Translational Gastroenterology GASTROENTEROLOGY & HEPATOLOGY-

CiteScore

7.00

自引率

0.00%

发文量

114

审稿时长

16 weeks

期刊介绍： Clinical and Translational Gastroenterology (CTG), published on behalf of the American College of Gastroenterology (ACG), is a peer-reviewed open access online journal dedicated to innovative clinical work in the field of gastroenterology and hepatology. CTG hopes to fulfill an unmet need for clinicians and scientists by welcoming novel cohort studies, early-phase clinical trials, qualitative and quantitative epidemiologic research, hypothesis-generating research, studies of novel mechanisms and methodologies including public health interventions, and integration of approaches across organs and disciplines. CTG also welcomes hypothesis-generating small studies, methods papers, and translational research with clear applications to human physiology or disease. Colon and small bowel Endoscopy and novel diagnostics Esophagus Functional GI disorders Immunology of the GI tract Microbiology of the GI tract Inflammatory bowel disease Pancreas and biliary tract Liver Pathology Pediatrics Preventative medicine Nutrition/obesity Stomach.