Multi-omics approach identifies gut microbiota variations associated with depression.

IF 7.8 1区生物学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

npj Biofilms and Microbiomes Pub Date : 2025-04-28 DOI:10.1038/s41522-025-00707-9

Adrián Hernández-Cacho, Jesús F García-Gavilán, Alessandro Atzeni, Prokopis Konstanti, Clara Belzer, Jesús Vioque, Dolores Corella, Montserrat Fitó, Josep Vidal, Virginia Mela, Liming Liang, Laura Torres-Collado, Oscar Coltell, Nancy Babio, Clary Clish, Javier Hernando-Redondo, Miguel Á Martínez-González, Fenglei Wang, Isabel Moreno-Indias, Jiaqi Ni, Courtney Dennis, Miguel Ruiz-Canela, Francisco J Tinahones, Frank B Hu, Jordi Salas-Salvadó

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引用次数: 0

Abstract

The gut microbiota plays a potential role in the pathophysiology of depression through the gut-brain axis. This cross-sectional study in 400 participants from the PREDIMED-Plus study investigates the interplay between gut microbiota and depression using a multi-omics approach. Depression was defined as antidepressant use or high Beck Depression Inventory-II scores. Gut microbiota was characterized by 16S rRNA sequencing, and faecal metabolites were analysed via liquid chromatography-tandem mass spectrometry. Participants with depression exhibited significant differences in gut microbial composition and metabolic profiles. Differentially abundant taxa included Acidaminococcus, Christensenellaceae R-7 group, and Megasphaera, among others. Metabolomic analysis revealed 15 significantly altered metabolites, primarily lipids, organic acids, and benzenoids, some of which correlated with gut microbial features. This study highlights the interplay between the gut microbiota and depression, paving the way for future research to determine whether gut microbiota influences depression pathophysiology or reflects changes associated with depression.

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多组学方法确定与抑郁症相关的肠道微生物群变异。

肠道微生物群通过肠-脑轴在抑郁症的病理生理中起着潜在的作用。这项来自PREDIMED-Plus研究的400名参与者的横断面研究使用多组学方法调查了肠道微生物群与抑郁症之间的相互作用。抑郁被定义为使用抗抑郁药或高贝克抑郁量表ii得分。采用16S rRNA测序对肠道菌群进行鉴定，采用液相色谱-串联质谱法分析粪便代谢物。抑郁症患者在肠道微生物组成和代谢谱方面表现出显著差异。差异丰富的分类群包括Acidaminococcus、Christensenellaceae R-7 group和Megasphaera等。代谢组学分析显示，15种代谢物发生了显著变化，主要是脂质、有机酸和苯类，其中一些与肠道微生物特征相关。该研究强调了肠道微生物群与抑郁症之间的相互作用，为未来研究确定肠道微生物群是否影响抑郁症病理生理或反映与抑郁症相关的变化铺平了道路。

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来源期刊

npj Biofilms and Microbiomes Immunology and Microbiology-Microbiology

CiteScore

12.10

自引率

3.30%

发文量

审稿时长

9 weeks

期刊介绍： npj Biofilms and Microbiomes is a comprehensive platform that promotes research on biofilms and microbiomes across various scientific disciplines. The journal facilitates cross-disciplinary discussions to enhance our understanding of the biology, ecology, and communal functions of biofilms, populations, and communities. It also focuses on applications in the medical, environmental, and engineering domains. The scope of the journal encompasses all aspects of the field, ranging from cell-cell communication and single cell interactions to the microbiomes of humans, animals, plants, and natural and built environments. The journal also welcomes research on the virome, phageome, mycome, and fungome. It publishes both applied science and theoretical work. As an open access and interdisciplinary journal, its primary goal is to publish significant scientific advancements in microbial biofilms and microbiomes. The journal enables discussions that span multiple disciplines and contributes to our understanding of the social behavior of microbial biofilm populations and communities, and their impact on life, human health, and the environment.