Age and BMI-related changes in hormonal profile in women with polycystic ovary syndrome (PCOS): Association with infertility.

Abstract

Objective: The aim of the study was to evaluate age- and body mass index (BMI, calculated as weight in kilograms divided by the square of height in meters)-related changes in hormonal profile in women with PCOS and to compare hormonal changes among women with polycystic ovary syndrome (PCOS) with and without infertility.

Methods: In this case-control study, conducted from March 2018 to January 2024, we enrolled women with PCOS with infertility (n = 265) and controls (n = 265) matched for age and BMI at the Department of Endocrinological Gynecology in University Hospital, Krakow, Poland. The assessment of anti-Müllerian hormone (AMH) along with hormonal profile including follicle-stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E₂), androgens (testosterone, 17-hydroxyprogesterone [17-OHP], dehydroepiandrosterone sulfate [DHEA-S]) as well as sex-hormone binding globulin was performed among these women, after assignment to different age BMI groups.

Results: Women with POCS and infertility showed higher AMH (+42.9%), E₂ (+15.9%) and LH (+41.9%) along with increased androgen levels reflected by increased testosterone (+20%), DHEA-S (+28.7%) and lower FSH (-10.3%) in contrary to women without infertility. Younger women (≤25 years) showed higher AMH, LH and androgens levels (total testosterone and DHEA-S) with lower FSH concentration. Women with higher BMI (≥30) had lower AMH together with increased free androgen index (FAI) and decreased sex hormone binding globulin (SHBG).

Conclusion: Infertile women with PCOS represent higher AMH together with elevated total testosterone, DHEA-S and FAI levels in contrary to fertile ones. Higher BMI together with older age have a negative impact on AMH in women with PCOS.