Evaluating treatment outcome of Glioblastoma with Stupp's regimen: an experienced in single Institute.

Abstract

Background: The current conventional treatment approach for newly diagnosed glioblastomas (GBMs) entails the complete removal of the tumor, followed by the implementation of Stupp's procedure. The main purpose of this study was to analyze the results of Stupp's treatment protocol in real-world practice and examine certain prognostic markers associated with survival, which could offer empirical evidence in the treatment of GBM.

Methods: A total of 64 patients diagnosed with newly developed GBM underwent treatment with irradiation and temozolomide (TMZ) at Vietnam National Cancer Hospital (VNCH) from January 2020 to September 2022. The study provided information on the demographic and clinical features of the patients, as well as their overall survival (OS) and progression-free survival (PFS) outcomes. The analysis of survival and related variables involved the utilization of Kaplan-Meier curves, Cox regression, and the log-rank test.

Results: The retrospective analysis comprised 64 participants. The vast majority of patients were in favorable performance status. The median OS and PFS were 21.91 and 9.39 months, respectively. Several factors, such as female patients, gross tumor resection/subtotal tumor resection (GTR/STR), time to start radiotherapy (RT) within 8 weeks postoperative, no progressive disease after concurrent chemoradiotherapy (CCRT), no dexamethasone required and Ki-67 level below 15%, were associated with increased OS. Regarding PFS, characteristics such as age <40 years old, GTR/STR and no disease progression following CCRT were substantially related to improved survival. Nearly half of patients received TMZ 50 mg/m2 in combination with bevacizumab following the initial progressive illness.

Conclusions: Multidisciplinary collaboration, as well as advancements in diagnosis and customized treatment strategies, are critical in the treatment of GBM patients. In actual life, completing the entire Stupp's protocol significantly improves GBM survival.