Exploring the influence of extra-corporeal membrane oxygenation (ECMO) support on neurodevelopmental outcomes in paediatric cardiac patients: a systematic review.

IF 0.9 4区医学 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS

Cardiology in the Young Pub Date : 2025-05-01 Epub Date: 2025-05-08 DOI:10.1017/S1047951125001635

Jeevan Francis, Ashwini Chandiramani, Alan George, Joseph George, Tim Jones

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引用次数: 0

Abstract

Background: Mechanical circulatory support, and specifically extra-corporeal membrane oxygenation, plays a critical role in managing paediatric cardiac patients with severe heart failure. Whilst these technologies are vital for bridging patients to recovery or heart transplantation, it is imperative to study the influence of extra-corporeal membrane oxygenation on neurodevelopmental outcomes.

Objectives: This systematic review aimed to evaluate the influence of extra-corporeal membrane oxygenation on neurodevelopmental outcomes in paediatric cardiac patients, both post-cardiotomy and non-cardiotomy patients were included.

Methodology: A comprehensive search was conducted using PubMed, EMBASE, and PsychInfo to identify primary research articles exploring the effects of extra-corporeal membrane oxygenation on neurodevelopmental outcomes in paediatric heart patients from inception to June 2024.

Results: Our search yielded 5488 papers of which eight papers were included featuring 302 patients.

Conclusion: The discussion highlights the considerable variability in neurodevelopmental outcomes and how they are measured among extra-corporeal membrane oxygenation survivors. Outcomes vary by patient factors, with recovery potential influenced by the duration and timing of follow-up. We emphasised the importance of standardised assessment tools and extended follow-ups to gain a clearer understanding of these outcomes.

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探讨体外膜氧合（ECMO）支持对儿科心脏病患者神经发育结局的影响：一项系统综述。

背景：机械循环支持，特别是体外膜氧合，在治疗严重心力衰竭的儿科心脏病患者中起着关键作用。虽然这些技术对于弥合患者康复或心脏移植至关重要，但研究体外膜氧合对神经发育结果的影响是必要的。目的：本系统综述旨在评估体外膜氧合对小儿心脏患者神经发育结局的影响，包括心脏切开和非心脏切开患者。方法：利用PubMed、EMBASE和PsychInfo进行综合检索，以确定从开始到2024年6月探讨体外膜氧合对儿科心脏病患者神经发育结局影响的主要研究文章。结果：我们检索到5488篇论文，其中包括8篇论文，涉及302例患者。结论：讨论强调了神经发育结果的相当大的变异性，以及如何在体外膜氧合幸存者中测量它们。结果因患者因素而异，恢复潜力受随访时间和时间的影响。我们强调了标准化评估工具和扩展随访的重要性，以更清楚地了解这些结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cardiology in the Young 医学-小儿科

CiteScore

1.70

自引率

10.00%

发文量

715

审稿时长

4-8 weeks

期刊介绍： Cardiology in the Young is devoted to cardiovascular issues affecting the young, and the older patient suffering the sequels of congenital heart disease, or other cardiac diseases acquired in childhood. The journal serves the interests of all professionals concerned with these topics. By design, the journal is international and multidisciplinary in its approach, and members of the editorial board take an active role in the its mission, helping to make it the essential journal in paediatric cardiology. All aspects of paediatric cardiology are covered within the journal. The content includes original articles, brief reports, editorials, reviews, and papers devoted to continuing professional development.