Clinical Significance of Epigenetic Factors in the Development of Tumor Cell Resistance to the Cytotoxic Activity of Macrophages.

IF 0.9 4区医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL

Bulletin of Experimental Biology and Medicine Pub Date : 2025-03-01 Epub Date: 2025-04-28 DOI:10.1007/s10517-025-06387-x

O V Kovaleva, P A Podlesnaya, E S Kudinova, V V Sinyov, V V Mochalnikova, N E Kushlinskii, A N Gratchev

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引用次数: 0

Abstract

The expression of long non-coding RNAs (lncRNAs) PSMB8-AS1 and IGFL2-AS1, as well as associated microRNAs miR-802 and miR-382-3p, was analyzed in 42 paired samples of non-small cell lung cancer (NSCLC) with subsequent evaluation of their diagnostic and prognostic significance. The expression of PSMB8-AS1 was reduced in tumor tissue compared to normal lung tissue, while the expression levels of IGFL2-AS1, miR-802, and miR-382-3p were increased. The analysis of the clinical significance of the studied molecules showed that the expression of PSMB8-AS1 correlated with the histological type and localization of the tumor (r = -0.532, p = 0.0003, and r = -0.475, p = 0.003, respectively). ROC analysis for PSMB8-AS1 in the group of patients with squamous cell carcinoma showed that the area under the ROC curve was 0.904 (p < 0.0001), indicating good quality of the diagnostic model and allows us to use the data obtained to further verify it. The analysis of the prognostic significance has shown that the studied non-coding RNAs in general are not prognostic factors for NSCLC. Additional subgroup analysis showed that PSMB8-AS1 is an unfavorable prognostic factor for squamous cell lung cancer (hazard ratio (HR)= 4.482, p = 0.027). Further investigation of non-coding RNAs in NSCLC is promising for identifying new markers for the diagnosis and prognosis of this disease.

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表观遗传因素在肿瘤细胞抵抗巨噬细胞细胞毒活性发展中的临床意义。

我们分析了42对非小细胞肺癌（NSCLC）配对样本中长链非编码rna (lncRNAs) PSMB8-AS1和IGFL2-AS1以及相关microRNAs miR-802和miR-382-3p的表达，并随后评估了它们的诊断和预后意义。与正常肺组织相比，PSMB8-AS1在肿瘤组织中的表达降低，而IGFL2-AS1、miR-802、miR-382-3p的表达水平升高。对所研究分子的临床意义分析显示，PSMB8-AS1的表达与肿瘤的组织学类型和定位相关（r = -0.532, p = 0.0003, r = -0.475, p = 0.003）。对鳞状细胞癌患者组的PSMB8-AS1进行ROC分析，ROC曲线下面积为0.904 (p < 0.0001)，表明该诊断模型质量较好，我们可以利用所得数据进一步验证。预后意义分析表明，所研究的非编码rna一般不是NSCLC的预后因素。另外亚组分析显示PSMB8-AS1是鳞状细胞肺癌的不利预后因素（危险比(HR)= 4.482, p = 0.027）。对非编码rna在非小细胞肺癌中的进一步研究有望为该病的诊断和预后提供新的标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Bulletin of Experimental Biology and Medicine 医学-医学：研究与实验

CiteScore

1.50

自引率

14.30%

发文量

265

审稿时长

2 months

期刊介绍： Bulletin of Experimental Biology and Medicine presents original peer reviewed research papers and brief reports on priority new research results in physiology, biochemistry, biophysics, pharmacology, immunology, microbiology, genetics, oncology, etc. Novel trends in science are covered in new sections of the journal - Biogerontology and Human Ecology - that first appeared in 2005. World scientific interest in stem cells prompted inclusion into Bulletin of Experimental Biology and Medicine a quarterly scientific journal Cell Technologies in Biology and Medicine (a new Russian Academy of Medical Sciences publication since 2005). It publishes only original papers from the leading research institutions on molecular biology of stem and progenitor cells, stem cell as the basis of gene therapy, molecular language of cell-to-cell communication, cytokines, chemokines, growth and other factors, pilot projects on clinical use of stem and progenitor cells. The Russian Volume Year is published in English from April.