Effects of fourteen essential minerals and vitamins on acute and chronic tubulointerstitial nephritis: a multivariate Mendelian randomization study.

IF 2.5 3区生物学

Hereditas Pub Date : 2025-04-16 DOI:10.1186/s41065-025-00383-x

Xiaotan Pan, Zhiyan Guo, Yin Zheng, Cheng Su, Jiabo Chen

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引用次数: 0

Abstract

Objective: To investigate the causal relationship between minerals and vitamins and acute and chronic tubulointerstitial nephritis by Mendelian randomization.

Methods: We selected fourteen minerals and vitamins from the GWAS database and acute tubulointerstitial nephritis and chronic tubulointerstitial nephritis from the Finnish database. Minerals and vitamins were first analyzed by two-sample Mendelian randomization for acute and chronic tubulointerstitial nephritis. The effects of minerals and vitamins on common acute and chronic tubulointerstitial nephritis were further explored by multivariate Mendelian randomization.

Results: among fourteen minerals and vitamins by two-sample Mendelian randomization analysis, there was genetic causality for vitamin B6 and vitamin D on acute tubulointerstitial nephritis, and the results were vitamin B6 (β = -0.641; P = 0.049; OR = 0.527; 95% CI: 0.278-0.998); vitamin D (β = -3.165; P = 0.040; OR = 0.042; 95% CI: 0.002-0.861). Fourteen minerals and vitamins were not genetically causally associated with chronic tubulointerstitial nephritis. The presence of vitamin B6 was then analyzed by a multivariate Mendelian randomization study to independently affect acute tubulointerstitial nephritis and showed a negative correlation (P = 0.010; 95% CI: 0.021-0.159).

Conclusion: We genetically predicted the possible influence of minerals and vitamins on acute and chronic tubulointerstitial nephritis. Vitamin B6 deficiency in vivo was found to adversely affect acute and chronic tubulointerstitial nephritis. This suggests that we pay clinical attention to the different effects that nutrients such as minerals and vitamins bring to acute and chronic tubulointerstitial nephritis.

Clinical trial number: Not applicable.

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14种必需矿物质和维生素对急性和慢性肾小管间质性肾炎的影响：一项多变量孟德尔随机研究。

目的：采用孟德尔随机法探讨矿物质和维生素与急慢性肾小管间质性肾炎的因果关系。方法：我们从GWAS数据库和急性肾小管间质性肾炎和慢性肾小管间质性肾炎芬兰数据库中选择了14种矿物质和维生素。矿物质和维生素首先通过两样本孟德尔随机化分析急性和慢性肾小管间质性肾炎。通过多变量孟德尔随机分组进一步探讨矿物质和维生素对常见急慢性肾小管间质性肾炎的影响。结果：经双样本孟德尔随机化分析，在14种矿物质和维生素中，维生素B6和维生素D与急性肾小管间质性肾炎存在遗传因果关系，结果为维生素B6 (β = -0.641；p = 0.049；or = 0.527；95% ci: 0.278-0.998)；维生素D (β = -3.165；p = 0.040；or = 0.042；95% ci: 0.002-0.861)。14种矿物质和维生素与慢性肾小管间质性肾炎没有遗传上的因果关系。然后通过多变量孟德尔随机化研究分析维生素B6的存在是否独立影响急性肾小管间质性肾炎，并显示出负相关(P = 0.010；95% ci: 0.021-0.159)。结论：从遗传学角度预测了矿物质和维生素对急慢性肾小管间质性肾炎的可能影响。体内维生素B6缺乏被发现对急性和慢性肾小管间质性肾炎有不利影响。提示临床应重视矿物质、维生素等营养物质对急慢性肾小管间质性肾炎的不同作用。临床试验号：不适用。

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来源期刊

Hereditas Biochemistry, Genetics and Molecular Biology-Genetics

CiteScore

3.80

自引率

3.70%

发文量

期刊介绍： For almost a century, Hereditas has published original cutting-edge research and reviews. As the Official journal of the Mendelian Society of Lund, the journal welcomes research from across all areas of genetics and genomics. Topics of interest include human and medical genetics, animal and plant genetics, microbial genetics, agriculture and bioinformatics.