Reductive Deuteration of Aldehydes/Ketones for the Synthesis of Monodeuterated Phosphinates and Derivatives Using D2O as the Nucleophilic Deuterium Source.

IF 3.3 2区化学 Q1 CHEMISTRY, ORGANIC

Journal of Organic Chemistry Pub Date : 2025-05-14 DOI:10.1021/acs.joc.5c00235

Xiaochen Niu,Yuanyuan Xie,Hongwei Zhou

引用次数: 0

Abstract

The ideal deuteration, for organic synthetic chemists, might include the use of a cheap deuterium source, mild operating conditions, and diverse transformations. We developed an umpolung sequence for the reductive deuteration of aldehydes/ketones, affording synthetically useful monodeuterated phosphinates. The further one-pot transformation and plausible mechanism of this reaction were studied.

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以D2O为亲核氘源合成单氘化膦酸盐及其衍生物的醛/酮还原氘化反应

对于有机合成化学家来说，理想的氘化可能包括使用廉价的氘源、温和的操作条件和多种转化。我们开发了一个用于醛/酮还原氘化的umpolung序列，提供合成有用的单氘化膦酸盐。进一步研究了该反应的一锅转化和可能的机理。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Organic Chemistry 化学-有机化学

CiteScore

6.20

自引率

11.10%

发文量

1467

审稿时长

2 months

期刊介绍： Journal of Organic Chemistry welcomes original contributions of fundamental research in all branches of the theory and practice of organic chemistry. In selecting manuscripts for publication, the editors place emphasis on the quality and novelty of the work, as well as the breadth of interest to the organic chemistry community.