Association of Cognitive Impairment and Peripheral Inflammation in Methamphetamine-dependent Patients: A Cross-sectional Study on Neuroinflammatory Markers TNF-α and IL-6.

IF 2.4 4区医学 Q3 NEUROSCIENCES

Clinical Psychopharmacology and Neuroscience Pub Date : 2025-05-31 Epub Date: 2025-01-20 DOI:10.9758/cpn.24.1236

Kannika Permpoonputtana, Jatuporn Namyen, Doungjai Buntup, Parichart Boontem, Chutikorn Nopparat, Piyarat Govitrapong

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引用次数: 0

Abstract

Objective: To investigate the cognitive impairment and peripheral inflammation induced by methamphetamine (METH) and their association in METH abusers.

Methods: The cross-sectional study included 100 METH-dependent patients and 100 healthy controls. Cognitive screening was conducted using the Thai version of the Montreal Cognitive Assessment (MoCA-T). Thirty normal controls and 30 METH-dependent patients were randomly selected for blood collection to measure inflammatory markers, including tumor necrosis factor (TNF)-α, interleukin (IL)-1β, and IL-6, using a quantitative enzyme-linked immunosorbent assay method.

Results: METH-dependent patients had significantly poorer MoCA-T scores and higher levels of blood inflammatory markers compared to healthy controls. Demographic characteristics, METH use patterns, and proinflammatory cytokines were associated with cognitive impairment. The MoCA-T score was negatively associated with plasma TNF-α and IL-6 levels.

Conclusion: METH-associated cognitive decline is correlated with elevated plasma levels of TNF-α and IL-6 cytokines, indicating the involvement of specific neuroinflammatory pathways in neurocognitive dysfunction. These insights could pave the way for novel therapeutic strategies aimed at mitigating neuroinflammation, potentially improving outcomes for individuals with METH addiction.

查看原文本刊更多论文

甲基苯丙胺依赖患者认知障碍与外周炎症的关联：神经炎症标志物TNF-α和IL-6的横断面研究

目的：探讨甲基苯丙胺（methamphetamine，简称冰毒）致认知功能障碍和外周炎症及其相关性。方法：横断面研究包括100例甲基苯丙胺依赖患者和100例健康对照。认知筛查使用泰国版蒙特利尔认知评估（MoCA-T）进行。随机选取30例正常对照和30例甲基甲醚依赖患者进行采血，采用定量酶联免疫吸附法测定炎症标志物，包括肿瘤坏死因子(TNF)-α、白细胞介素(IL)-1β和IL-6。结果：与健康对照者相比，冰毒依赖患者的MoCA-T评分明显较低，血液炎症标志物水平较高。人口统计学特征、冰毒使用模式和促炎细胞因子与认知障碍有关。MoCA-T评分与血浆TNF-α、IL-6水平呈负相关。结论：甲基甲醚相关认知功能下降与血浆TNF-α和IL-6细胞因子水平升高有关，提示特定的神经炎症通路参与了神经认知功能障碍。这些见解可以为旨在减轻神经炎症的新治疗策略铺平道路，潜在地改善冰毒成瘾者的预后。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Psychopharmacology and Neuroscience NEUROSCIENCESPHARMACOLOGY & PHARMACY-PHARMACOLOGY & PHARMACY

CiteScore

4.70

自引率

12.50%

发文量

期刊介绍： Clinical Psychopharmacology and Neuroscience (Clin Psychopharmacol Neurosci) launched in 2003, is the official journal of The Korean College of Neuropsychopharmacology (KCNP), and the associate journal for Asian College of Neuropsychopharmacology (AsCNP). This journal aims to publish evidence-based, scientifically written articles related to clinical and preclinical studies in the field of psychopharmacology and neuroscience. This journal intends to foster and encourage communications between psychiatrist, neuroscientist and all related experts in Asia as well as worldwide. It is published four times a year at the last day of February, May, August, and November.