{"title":"Unraveling white matter alterations in autism: the role of oligodendrocytes, microglia, and neuroinflammation.","authors":"Yuri Bozzi","doi":"10.1093/cercor/bhaf094","DOIUrl":null,"url":null,"abstract":"<p><p>Researchers are increasingly investigating the developmental origins of white matter alterations in autism spectrum disorder (ASD). A recent review by Canada, Evans, and Pelphrey highlights the roles of oligodendrocytes and microglia in ASD-related white matter abnormalities. Evidence suggests that ASD risk genes impact oligodendrocyte development and myelination, while microglia dysfunction due to immune challenges may further disrupt white matter formation. Emerging studies link neuroinflammation to altered white matter trajectories, supporting early intervention strategies. Future research integrating neuroimaging, genetics, and immune profiling may enhance our understanding and facilitate the development of targeted neuroimmune therapies for ASD.</p>","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"35 4","pages":""},"PeriodicalIF":2.9000,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cerebral cortex","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1093/cercor/bhaf094","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"NEUROSCIENCES","Score":null,"Total":0}
引用次数: 0
Abstract
Researchers are increasingly investigating the developmental origins of white matter alterations in autism spectrum disorder (ASD). A recent review by Canada, Evans, and Pelphrey highlights the roles of oligodendrocytes and microglia in ASD-related white matter abnormalities. Evidence suggests that ASD risk genes impact oligodendrocyte development and myelination, while microglia dysfunction due to immune challenges may further disrupt white matter formation. Emerging studies link neuroinflammation to altered white matter trajectories, supporting early intervention strategies. Future research integrating neuroimaging, genetics, and immune profiling may enhance our understanding and facilitate the development of targeted neuroimmune therapies for ASD.
期刊介绍：
Cerebral Cortex publishes papers on the development, organization, plasticity, and function of the cerebral cortex, including the hippocampus. Studies with clear relevance to the cerebral cortex, such as the thalamocortical relationship or cortico-subcortical interactions, are also included.
The journal is multidisciplinary and covers the large variety of modern neurobiological and neuropsychological techniques, including anatomy, biochemistry, molecular neurobiology, electrophysiology, behavior, artificial intelligence, and theoretical modeling. In addition to research articles, special features such as brief reviews, book reviews, and commentaries are included.
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