Causal relationship between Parkinson's disease and gastric cancer: a Mendelian randomization study.

IF 2.2 3区医学 Q3 CLINICAL NEUROLOGY

BMC Neurology Pub Date : 2025-04-16 DOI:10.1186/s12883-025-04184-7

Jiayu Liu, Jiafeng Liu, Lanjun Li, Wenju Li, Ziyang Jiang, Gang Yin, Yunling Zhang, Yuan Sun

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引用次数: 0

Abstract

Background: Age-related diseases, including Parkinson's disease and gastric cancer, substantially affect the global aging population. Previous observational research has suggested a potential association between Parkinson's disease and gastric cancer; however, findings regarding this aspect have been inconsistent. In the present study, we used data from genome-wide association studies to infer a causal relationship between Parkinson's disease and gastric cancer based on genetic variations.

Methods: We used the two-sample Mendelian randomization method to analyze data from the genome-wide association study catalog, including 482,730 and 476,116 patients with Parkinson's disease and gastric cancer, respectively. Inverse-variance weighting was used as the primary Mendelian randomization analysis. We conducted sensitivity analyses to evaluate heterogeneity and pleiotropy, followed by two-step Mendelian randomization to ascertain the latent mediator of the relationship between Parkinson's disease and gastric cancer.

Results: Our results suggested a causal negative relationship between Parkinson's disease and gastric cancer. Heterogeneity and pleiotropy analyses confirmed the robustness of the inverse-variance weighting results. Furthermore, P2X6 was identified as a key factor mediating this negative causal relationship.

Conclusions: Patients with Parkinson's disease may have a lower risk of developing gastric cancer, with P2X6 serving as a significant mediating variable. These novel insights can aid the development of potential therapeutic targets for patients with Parkinson's disease or gastric cancer.

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帕金森病与胃癌的因果关系：一项孟德尔随机研究

背景：与年龄相关的疾病，包括帕金森病和胃癌，严重影响着全球老龄化人口。先前的观察性研究表明帕金森病与胃癌之间存在潜在关联；然而，关于这方面的研究结果并不一致。在本研究中，我们使用全基因组关联研究的数据，基于遗传变异推断帕金森病和胃癌之间的因果关系。方法：采用双样本孟德尔随机化方法分析全基因组关联研究目录中的数据，分别包括482730例帕金森病和476116例胃癌患者。反方差加权作为主要的孟德尔随机化分析。我们通过敏感性分析来评估异质性和多效性，然后通过两步孟德尔随机化来确定帕金森病和胃癌之间关系的潜在中介。结果：帕金森病与胃癌呈负相关。异质性和多效性分析证实了反方差加权结果的稳健性。此外，P2X6被确定为中介这种负相关因果关系的关键因素。结论：帕金森病患者发生胃癌的风险可能较低，P2X6是一个重要的中介变量。这些新发现有助于开发帕金森病或胃癌患者的潜在治疗靶点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

BMC Neurology 医学-临床神经学

CiteScore

4.20

自引率

0.00%

发文量

428

审稿时长

3-8 weeks

期刊介绍： BMC Neurology is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of neurological disorders, as well as related molecular genetics, pathophysiology, and epidemiology.