M A Asanov, A O Poddubnyak, A V Sinitskaya, M V Khutornaya, O V Khryachkova, M Yu Sinitsky
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引用次数: 0
Abstract
The effect of doxorubicin on the relative telomere length of cardiomyocytes in Wistar rats was studied. Doxorubicin (2 mg/kg body weight) was injected into the caudal vein once a week for 4 weeks, the control group was injected with 0.9% NaCl solution in an equivalent volume. The serum concentrations of proinflammatory cytokines (MCP-1 and TNFα), oxidative stress marker 8-hydroxydeoxyguanosine (8-OHdG), and telomerase reverse transcriptase (TERT) were measured. In rats treated with doxorubicin, the relative length of cardiomyocyte telomeres and serum levels of 8-OHdG were higher than the in control. Thus, molecular effects of subchronic low-dose doxorubicin exposure in rats were revealed: telomeric regions of cardiomyocyte DNA were lengthened, and the level of oxidative stress marker increased.
期刊介绍：
Bulletin of Experimental Biology and Medicine presents original peer reviewed research papers and brief reports on priority new research results in physiology, biochemistry, biophysics, pharmacology, immunology, microbiology, genetics, oncology, etc. Novel trends in science are covered in new sections of the journal - Biogerontology and Human Ecology - that first appeared in 2005.
World scientific interest in stem cells prompted inclusion into Bulletin of Experimental Biology and Medicine a quarterly scientific journal Cell Technologies in Biology and Medicine (a new Russian Academy of Medical Sciences publication since 2005). It publishes only original papers from the leading research institutions on molecular biology of stem and progenitor cells, stem cell as the basis of gene therapy, molecular language of cell-to-cell communication, cytokines, chemokines, growth and other factors, pilot projects on clinical use of stem and progenitor cells.
The Russian Volume Year is published in English from April.
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