Xiaojuan Chou, Wenhua Zha, Jian Hu, Chen Chen, Rajesh K Singh, Geng Liu
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引用次数: 0
Abstract
Background: The management of acute pain is a crucial and challenging component of emergency care. The pursuit of an ideal drug that alleviates pain rapidly and with fewer side effects is an ongoing endeavor.
Objective: This meta-analysis reviews the safety and efficacy of ketamine in adult emergency department (ED) patients experiencing acute pain.
Methodology: This study was limited to randomized controlled trials (RCTs). The comparative group was morphine or other opioids or placebo, whereas the experimental group was ketamine. The primary outcome measures, in addition to adverse events, were the numeric rating scale (NRS). The included studies were subjected to analysis using the Review Manager Database. The non-significant changes in pain score were observed in the ketamine group at 10 minutes [- 0.46 (-2.03, 1.10)], 30 minutes [-0.13 (-0.62, 0.37)], and 60 minutes [-0.18 (-0.97, 0.61)] as compared to the control group.
Results: The significant changes were observed at 15 minutes [-4.11 (-7.91, -0.31)] in the ketamine group as compared to the control group. The overall risk ratio (1.20 [95% Confidence interval (CI), 0.93 to 1.55] indicated a non-significant difference in adverse events in the control group as compared to the ketamine group. The heterogeneity among included studies was found to be higher, as indicated by the I2 statistics.
Conclusion: There were no significant differences in adverse events between the ketamine and the control groups. More randomized clinical trials are needed to determine ketamine's involvement in acute pain at 10, 30, and 60 minutes.
期刊介绍：
Combinatorial Chemistry & High Throughput Screening (CCHTS) publishes full length original research articles and reviews/mini-reviews dealing with various topics related to chemical biology (High Throughput Screening, Combinatorial Chemistry, Chemoinformatics, Laboratory Automation and Compound management) in advancing drug discovery research. Original research articles and reviews in the following areas are of special interest to the readers of this journal:
Target identification and validation
Assay design, development, miniaturization and comparison
High throughput/high content/in silico screening and associated technologies
Label-free detection technologies and applications
Stem cell technologies
Biomarkers
ADMET/PK/PD methodologies and screening
Probe discovery and development, hit to lead optimization
Combinatorial chemistry (e.g. small molecules, peptide, nucleic acid or phage display libraries)
Chemical library design and chemical diversity
Chemo/bio-informatics, data mining
Compound management
Pharmacognosy
Natural Products Research (Chemistry, Biology and Pharmacology of Natural Products)
Natural Product Analytical Studies
Bipharmaceutical studies of Natural products
Drug repurposing
Data management and statistical analysis
Laboratory automation, robotics, microfluidics, signal detection technologies
Current & Future Institutional Research Profile
Technology transfer, legal and licensing issues
Patents.
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