Reaching for more: How reproduction transforms the maternal intestine

IF 45.5 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Cell Pub Date : 2025-05-15 DOI:10.1016/j.cell.2025.04.024

Maria H. Festing, Kubra B. Akkaya-Colak, Maria M. Mihaylova

引用次数: 0

Abstract

Several organs undergo changes during pregnancy to accommodate fetal growth, including the small intestine. However, the signals that trigger this intestinal remodeling are not well understood. In a recent study, Ameku et al. describe an anticipatory intestinal growth program that is partially irreversible and supported by SGLT3a-dependent increase of Fgfbp1-positive progenitor cells.

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追求更多：生殖如何改变母肠

几个器官在怀孕期间发生变化以适应胎儿的生长，包括小肠。然而，引发这种肠道重塑的信号尚未得到很好的理解。在最近的一项研究中，Ameku等人描述了一种预期肠道生长程序，该程序部分不可逆，并由fgfbp1阳性祖细胞的sglt3a依赖性增加所支持。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell 生物-生化与分子生物学

CiteScore

110.00

自引率

0.80%

发文量

396

审稿时长

2 months

期刊介绍： Cells is an international, peer-reviewed, open access journal that focuses on cell biology, molecular biology, and biophysics. It is affiliated with several societies, including the Spanish Society for Biochemistry and Molecular Biology (SEBBM), Nordic Autophagy Society (NAS), Spanish Society of Hematology and Hemotherapy (SEHH), and Society for Regenerative Medicine (Russian Federation) (RPO). The journal publishes research findings of significant importance in various areas of experimental biology, such as cell biology, molecular biology, neuroscience, immunology, virology, microbiology, cancer, human genetics, systems biology, signaling, and disease mechanisms and therapeutics. The primary criterion for considering papers is whether the results contribute to significant conceptual advances or raise thought-provoking questions and hypotheses related to interesting and important biological inquiries. In addition to primary research articles presented in four formats, Cells also features review and opinion articles in its "leading edge" section, discussing recent research advancements and topics of interest to its wide readership.