Human mitochondrial DNA in public metagenomes: Opportunity or privacy threat?

IF 45.5 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Cell Pub Date : 2025-05-15 DOI:10.1016/j.cell.2025.03.023

Mohamed S. Sarhan, Giacomo Antonello, Hansi Weissensteiner, Claudia Mengoni, Deborah Mascalzoni, Levi Waldron, Nicola Segata, Christian Fuchsberger

引用次数: 0

Abstract

Human DNA is unavoidably present in metagenomic analyses of human microbiomes. While current protocols remove human DNA before submission to public repositories, mitochondrial DNA (mtDNA) has been overlooked and frequently persists. We discuss the privacy risks and research opportunities associated with mtDNA, urging consideration by the scientific, ethics, and legal communities.

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公共宏基因组中的人类线粒体DNA：机遇还是隐私威胁？

人类DNA不可避免地存在于人类微生物组的宏基因组分析中。虽然目前的协议在提交给公共存储库之前删除了人类DNA，但线粒体DNA （mtDNA）一直被忽视并且经常持续存在。我们讨论了与mtDNA相关的隐私风险和研究机会，敦促科学、伦理和法律界予以考虑。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell 生物-生化与分子生物学

CiteScore

110.00

自引率

0.80%

发文量

396

审稿时长

2 months

期刊介绍： Cells is an international, peer-reviewed, open access journal that focuses on cell biology, molecular biology, and biophysics. It is affiliated with several societies, including the Spanish Society for Biochemistry and Molecular Biology (SEBBM), Nordic Autophagy Society (NAS), Spanish Society of Hematology and Hemotherapy (SEHH), and Society for Regenerative Medicine (Russian Federation) (RPO). The journal publishes research findings of significant importance in various areas of experimental biology, such as cell biology, molecular biology, neuroscience, immunology, virology, microbiology, cancer, human genetics, systems biology, signaling, and disease mechanisms and therapeutics. The primary criterion for considering papers is whether the results contribute to significant conceptual advances or raise thought-provoking questions and hypotheses related to interesting and important biological inquiries. In addition to primary research articles presented in four formats, Cells also features review and opinion articles in its "leading edge" section, discussing recent research advancements and topics of interest to its wide readership.