Corneal hysteresis as a biomarker in glaucoma development among patients with myopia: a prospective study based on the UK Biobank

IF 3.7 2区医学 Q1 OPHTHALMOLOGY

British Journal of Ophthalmology Pub Date : 2025-05-14 DOI:10.1136/bjo-2024-326817

Jae-Seung Yun, Sang-Hyuk Jung, Seung Min Jung, Hong-Hee Won, Dokyoon Kim, Jin A Choi

{"title":"Corneal hysteresis as a biomarker in glaucoma development among patients with myopia: a prospective study based on the UK Biobank","authors":"Jae-Seung Yun, Sang-Hyuk Jung, Seung Min Jung, Hong-Hee Won, Dokyoon Kim, Jin A Choi","doi":"10.1136/bjo-2024-326817","DOIUrl":null,"url":null,"abstract":"Background/aims We investigated the impact of potential risk factors on the development of incident glaucoma in individuals with myopia. Methods This prospective cohort study investigated participants aged 40–69 years from the UK Biobank. Participants were classified based on the degree of myopia: non-myopic (spherical equivalent (SE)≤−0.5D), mild myopia (−3.0D<SE≤−0.5 D), moderate myopia (−6.0 D<SE≤−3.0 D) and high myopia (SE≤−6.0D). Cox proportional-hazard models assessed the relationship of ocular and systemic risk factors with new glaucoma events across the myopia subgroups. Results Of 105 548 participants who did not have prior glaucoma, 35 870 were classified as myopic and 69 678 as non-myopic. A total of 1877 incident glaucoma cases (1.78%) were documented during a median 11.1 years of follow-up. Those who developed glaucoma had lower SE, lower corneal hysteresis (CH) and higher intraocular pressure. Systemic factors such as type 2 diabetes, dyslipidaemia, baseline fasting blood sugar and haemoglobin A1c were significantly higher in those who developed glaucoma, but only in the non-myopia and mild myopia subgroups. Degree of myopia and low CH (≤10.1 mm Hg) were significantly associated with increased glaucoma incidence. When we explored the impact of CH on the risk of incident glaucoma according to myopia grade, consistent elevation of risk with low CH was observed, with the highest risk being exhibited in the high myopia population (HR 1.67 (95% CI 1.10 to 2.57)). Conclusions Our results demonstrated a significant joint association between CH and myopia regarding glaucoma development, suggesting that altered ocular biomechanical properties could play a pronounced role in glaucoma development, particularly within the highly myopic population. Data may be obtained from a third party and are not publicly available.","PeriodicalId":9313,"journal":{"name":"British Journal of Ophthalmology","volume":"196 1","pages":""},"PeriodicalIF":3.7000,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"British Journal of Ophthalmology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1136/bjo-2024-326817","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"OPHTHALMOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Background/aims We investigated the impact of potential risk factors on the development of incident glaucoma in individuals with myopia. Methods This prospective cohort study investigated participants aged 40–69 years from the UK Biobank. Participants were classified based on the degree of myopia: non-myopic (spherical equivalent (SE)≤−0.5D), mild myopia (−3.0D

查看原文本刊更多论文

角膜迟滞作为近视患者青光眼发展的生物标志物：基于UK Biobank的前瞻性研究

背景/目的研究近视患者发生偶发性青光眼的潜在危险因素。方法本前瞻性队列研究调查了来自英国生物银行年龄在40-69岁之间的参与者。参与者根据近视程度分为：非近视（SE≤- 0.5D）、轻度近视（- 3.0D

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

British Journal of Ophthalmology 医学-眼科学

CiteScore

10.30

自引率

2.40%

发文量

213

审稿时长

3-6 weeks

期刊介绍： The British Journal of Ophthalmology (BJO) is an international peer-reviewed journal for ophthalmologists and visual science specialists. BJO publishes clinical investigations, clinical observations, and clinically relevant laboratory investigations related to ophthalmology. It also provides major reviews and also publishes manuscripts covering regional issues in a global context.

京公网安备 11010802042870号

Book学术文献互助群
群号：481959085