Dose-effect Relationship of Hyperbaric Oxygen Therapy in Rats with Amnestic Mild Cognitive Impairment.

IF 2.2 4区医学 Q3 CLINICAL NEUROLOGY

Dementia and Geriatric Cognitive Disorders Pub Date : 2025-05-03 DOI:10.1159/000545906

Yi Chen, Xianzhong Lin, Qian Zhou, Xin Ling

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引用次数: 0

Abstract

Background: Amnestic mild cognitive impairment (aMCI) represents an intermediate stage between normal aging and dementia. Hyperbaric oxygen (HBO) therapy, has shown promise in enhancing brain oxygenation and promoting neural stem cell proliferation.

Methods: 80 SD male adult rats were randomly divided into control group, amnestic mild cognitive impairment group(aMCI group) and hyperbaric oxygen group(HBO group).The HBO group was divided into 6 subgroups according to different treatment pressures: 1.6ATA subgroup, 1.8ATA subgroup, 2.0ATA subgroup, 2.2ATA subgroup, 2.5ATA subgroup and 2.8ATA subgroup, with 10 in each group. The HBO group received hyperbaric oxygen therapy at the specified pressure for 60 minutes per day for 5 consecutive days.

Results: After hyperbaric oxygen treatment, compared with the aMCI group, the escape latency of each HBO subgroup was significantly shortened (p<0.001). The 2.0ATA subgroup (p=0.001), 2.2ATA subgroup (p=0.001)and 2.5ATA subgroup ( p=0.002) significantly increased the number of platform crossings.the levels of SOD were significantly increased in1.6ATA subgroup (p=0.019), 1.8ATA subgroup(p =0.003), 2.0ATA subgroup(p=0.010 ) and 2.2ATA group(p=0.016) and MDA contents were significantly decreased in the 1.6ATA subgroup(p=0.015), 1.8ATA subgroup(p =0.012), 2.0ATA subgroup(p=0.002), and 2.2ATA subgroups (p<0.001), and the levels of eNOS were significantly decreased in the 1.8ATA subgroup(p=0.007) and 2.0ATA subgroup (p=0.029),and the expression of nNOS were significantly decreased in the 1.8ATA subgroup (p=0.006),2.0ATA subgroup (p<0.001) and the 2.2ATA subgroup ( p< 0.001).

Conclusions: In aMCI model rats found that HBO treatment at a pressure of 2.0 ATA with a stabilization time of 60 minutes per day for 5 days was the most effective.

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高压氧治疗遗忘性轻度认知障碍大鼠的量效关系。

背景：遗忘性轻度认知障碍（aMCI）是介于正常衰老和痴呆之间的中间阶段。高压氧（HBO）治疗在增强脑氧合和促进神经干细胞增殖方面显示出前景。方法：80只SD雄性成年大鼠随机分为对照组、健忘性轻度认知障碍组（aMCI组）和高压氧组（HBO组）。HBO组根据治疗压力的不同分为1.6ATA亚组、1.8ATA亚组、2.0ATA亚组、2.2ATA亚组、2.5ATA亚组、2.8ATA亚组，每组10例。HBO组在规定压力下进行高压氧治疗，每天60分钟，连续5天。结果：高压氧治疗后，与aMCI组相比，各亚组HBO的逃逸潜伏期均明显缩短(p)。结论：aMCI模型大鼠发现，2.0 ATA压力下，稳定时间为60分钟/天，持续5天的高压氧治疗最有效。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Dementia and Geriatric Cognitive Disorders 医学-精神病学

CiteScore

4.70

自引率

0.00%

发文量

审稿时长

2 months

期刊介绍： As a unique forum devoted exclusively to the study of cognitive dysfunction, ''Dementia and Geriatric Cognitive Disorders'' concentrates on Alzheimer’s and Parkinson’s disease, Huntington’s chorea and other neurodegenerative diseases. The journal draws from diverse related research disciplines such as psychogeriatrics, neuropsychology, clinical neurology, morphology, physiology, genetic molecular biology, pathology, biochemistry, immunology, pharmacology and pharmaceutics. Strong emphasis is placed on the publication of research findings from animal studies which are complemented by clinical and therapeutic experience to give an overall appreciation of the field.