Congenitally corrected transposition of the great arteries and coronary artery disease: a case report in an 83-year-old male.

IF 0.8 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS
European Heart Journal: Case Reports Pub Date : 2025-05-07 eCollection Date: 2025-05-01 DOI:10.1093/ehjcr/ytaf161
Ahmed Alomrani, Mohammed Alshammari, Fahad Bindakhil, Hadi Shabi, Abdullah Alkhodair
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引用次数: 0

Abstract

Background: Congenitally corrected transposition of the great arteries (CCTGA), or L-loop TGA, is a rare congenital heart defect, comprising <1% of congenital heart diseases, with an incidence of ∼1 in 33 000 births. It is characterized by atrioventricular and ventriculo-arterial discordance, where the left ventricle connects to a right atrium and pumps deoxygenated blood into the pulmonary artery, while the right ventricle (RV) connects to a left atrium and pumps oxygenated blood into the aorta. Congenitally corrected transposition of the great arteries often coexists with other cardiac anomalies, although ∼10% of cases are isolated. A case report highlights a unique instance of coronary artery disease (CAD) in CCTGA.

Case summary: An 83-year-old male with CCTGA presented with persistent nausea, fatigue, poor oral intake, and epigastric pain. He had a history of hypertension, Type II diabetes, dyslipidaemia, ischaemic heart disease, and chronic atrial fibrillation. On examination, he was stable but showed signs of a urinary tract infection. A cardiac workup revealed no ischaemic changes on electrocardiography, but a cardiac computed tomography identified significant CAD involving multiple vessels. A decision was made to perform percutaneous coronary intervention on the right coronary artery, successfully placing two stents.

Discussion: In patients with CCTGA, major factors contributing to morbidity and mortality include progressive decline in systemic RV function and systemic tricuspid valve regurgitation. A retrospective study showed that 25% of uncomplicated CCTGA patients develop heart failure by age 45, while approximately two-thirds of complicated cases do. Survival beyond age 70 is rare. Prompt management of CAD through angioplasty is critical to prevent further deterioration of RV function and worsening tricuspid regurgitation. However, the atypical positioning of the aorta and coronary arteries complicates selective coronary angiography, making a challenging diagnosis and treatment.

先天性纠正大动脉转位和冠状动脉疾病:一例83岁男性报告。
背景:先天性纠正性大动脉转位(CCTGA),或l -环TGA,是一种罕见的先天性心脏缺陷,包括病例总结:一名83岁男性CCTGA,表现为持续恶心,疲劳,口食不良和胃脘痛。他有高血压、II型糖尿病、血脂异常、缺血性心脏病和慢性心房颤动病史。经检查,他情况稳定,但有尿路感染的迹象。心脏检查显示心电图无缺血性改变,但心脏计算机断层扫描发现累及多血管的显著CAD。我们决定对右冠状动脉进行经皮冠状动脉介入治疗,并成功放置了两个支架。讨论:在CCTGA患者中,导致发病率和死亡率的主要因素包括全身右心室功能的进行性下降和全身三尖瓣反流。一项回顾性研究显示,25%的无并发症CCTGA患者在45岁时发生心力衰竭,而大约三分之二的并发症患者会发生心力衰竭。活过70岁的人很少。通过血管成形术及时处理冠心病是防止右室功能进一步恶化和三尖瓣反流恶化的关键。然而,主动脉和冠状动脉的不典型定位使选择性冠状动脉造影复杂化,使诊断和治疗具有挑战性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
European Heart Journal: Case Reports
European Heart Journal: Case Reports Medicine-Cardiology and Cardiovascular Medicine
CiteScore
1.30
自引率
10.00%
发文量
451
审稿时长
14 weeks
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