Indicators of Endogenous Intoxication in Uncomplicated Pregnancy. Medium-Weight Molecules and Lipid Peroxidation Products.

IF 0.9 4区医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL

Bulletin of Experimental Biology and Medicine Pub Date : 2025-03-01 Epub Date: 2025-04-28 DOI:10.1007/s10517-025-06390-2

N V Semenova, O A Nikitina, E A Novikova, A N Karacheva, A Yu Marianian, S I Kolesnikov, A V Labygina, L I Kolesnikova

{"title":"Indicators of Endogenous Intoxication in Uncomplicated Pregnancy. Medium-Weight Molecules and Lipid Peroxidation Products.","authors":"N V Semenova, O A Nikitina, E A Novikova, A N Karacheva, A Yu Marianian, S I Kolesnikov, A V Labygina, L I Kolesnikova","doi":"10.1007/s10517-025-06390-2","DOIUrl":null,"url":null,"abstract":"<p><p>The endogenous intoxication level was assessed based on the content of medium-weight molecules (MWM) and LPO products in the blood serum of women with uncomplicated pregnancy depending on the gestational age: 6-12, 18-22, 28-32, and 38-40 weeks. A significant increase in the MWM level at λ = 280 nm was found at weeks 28-32 compared to the second trimester (p = 0.05), as well as before delivery compared to the first trimester (p = 0.013). In the third trimester of pregnancy and before delivery, the substrates with double bonds and diene conjugates content increased (p < 0.05), but the levels of highly toxic TBA-active products before delivery did not differ from that at the beginning of the gestation process. These phase changes in LPO processes correspond to changes in the hormonal status of the body during uncomplicated pregnancy, and MWM measured at λ = 280 nm is a sensitive marker for monitoring of the endogenous intoxication level.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":"178 5","pages":"643-646"},"PeriodicalIF":0.9000,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Bulletin of Experimental Biology and Medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s10517-025-06390-2","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/4/28 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"MEDICINE, RESEARCH & EXPERIMENTAL","Score":null,"Total":0}

引用次数: 0

Abstract

The endogenous intoxication level was assessed based on the content of medium-weight molecules (MWM) and LPO products in the blood serum of women with uncomplicated pregnancy depending on the gestational age: 6-12, 18-22, 28-32, and 38-40 weeks. A significant increase in the MWM level at λ = 280 nm was found at weeks 28-32 compared to the second trimester (p = 0.05), as well as before delivery compared to the first trimester (p = 0.013). In the third trimester of pregnancy and before delivery, the substrates with double bonds and diene conjugates content increased (p < 0.05), but the levels of highly toxic TBA-active products before delivery did not differ from that at the beginning of the gestation process. These phase changes in LPO processes correspond to changes in the hormonal status of the body during uncomplicated pregnancy, and MWM measured at λ = 280 nm is a sensitive marker for monitoring of the endogenous intoxication level.

查看原文本刊更多论文

无并发症妊娠中内源性中毒的指标。中等质量分子和脂质过氧化产物。

根据6-12周、18-22周、28-32周和38-40周的胎龄，根据无并发症妊娠妇女血清中中重分子（MWM）和LPO产物的含量评估内源性中毒水平。在28-32周，与妊娠中期相比，λ = 280 nm处的MWM水平显著增加（p = 0.05），分娩前与妊娠早期相比，MWM水平显著增加（p = 0.013）。在妊娠晚期和分娩前，含双键和二烯缀合物的底物含量增加（p < 0.05），但分娩前高毒性tba活性产物的含量与妊娠初期没有差异。LPO过程的这些相位变化与无并发症妊娠期间体内激素状态的变化相对应，在λ = 280 nm处测量的MWM是监测内源性中毒水平的敏感标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Bulletin of Experimental Biology and Medicine 医学-医学：研究与实验

CiteScore

1.50

自引率

14.30%

发文量

265

审稿时长

2 months

期刊介绍： Bulletin of Experimental Biology and Medicine presents original peer reviewed research papers and brief reports on priority new research results in physiology, biochemistry, biophysics, pharmacology, immunology, microbiology, genetics, oncology, etc. Novel trends in science are covered in new sections of the journal - Biogerontology and Human Ecology - that first appeared in 2005. World scientific interest in stem cells prompted inclusion into Bulletin of Experimental Biology and Medicine a quarterly scientific journal Cell Technologies in Biology and Medicine (a new Russian Academy of Medical Sciences publication since 2005). It publishes only original papers from the leading research institutions on molecular biology of stem and progenitor cells, stem cell as the basis of gene therapy, molecular language of cell-to-cell communication, cytokines, chemokines, growth and other factors, pilot projects on clinical use of stem and progenitor cells. The Russian Volume Year is published in English from April.