The Milan System SUMP Category: 5-Year Diagnostic Performance

IF 1 4区医学 Q4 MEDICAL LABORATORY TECHNOLOGY

Diagnostic Cytopathology Pub Date : 2025-05-06 DOI:10.1002/dc.25482

Henri Lagerstam, Erkka Tommola, David Kalfert, Saara Kares, Heini Huhtala, Ivana Kholová

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Abstract

Background

Salivary gland neoplasms are heterogeneous, with wide cytomorphological overlap. Neoplasms categorized in the Milan System for Reporting Salivary Gland Cytopathology (MSRSGC) as salivary gland neoplasms of uncertain malignant potential (SUMP) reflect this diagnostic challenge.

Methods

All salivary gland fine-needle aspirations (SG-FNA) diagnosed at Fimlab Laboratories over a 5-year period (January 1, 2018–December 31, 2022) that were classified as SUMP were included. Follow-ups were reviewed until May 31, 2024. The SUMP cases were classified into cytomorphological subtypes. The risk of malignancy (ROM), risk of neoplasm, and median timelines of the pathology laboratory workflow and patient management were calculated. In addition, separate analyses of the impact of age and sex were performed.

Results

A total of 1157 SG-FNAs were diagnosed over a 5-year period. Of these, 100 SG-FNAs from 52 females and 33 males were classified as SUMP. A total of 69 (69.0%) SUMP cases underwent histological verification. The ROM was 23.2% for all surgical follow-ups, 35.0% for the oncocytic/oncocytoid subtype, and 18.4% for the basaloid subtype. For the male and female groups, the ROMs were 26.9% and 16.2% for all surgical follow-ups, 40.0% and 14.3% for the oncocytic/oncocytoid subtype, and 18.8% and 16.7% for the basaloid subtype, respectively.

Conclusions

The 5-year analysis of SUMP category performance showed a lower ROM in our practice than the MSRSGC reference value. The oncocytic/oncocytoid subtype presented a higher ROM than the basaloid subtype. The ROMs were highest in the male population and in the age group of 30–69 years.

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米兰系统SUMP类别：5年诊断性能。

背景：唾液腺肿瘤是异质性的，具有广泛的细胞形态重叠。在米兰唾液腺细胞病理学报告系统（MSRSGC）中被归类为恶性潜能不确定的唾液腺肿瘤（SUMP）的肿瘤反映了这一诊断挑战。方法：纳入5年内（2018年1月1日至2022年12月31日）在Fimlab实验室诊断的所有归类为SUMP的唾液腺细针穿刺（SG-FNA）。后续审查截止到2024年5月31日。SUMP病例被划分为细胞形态学亚型。计算恶性肿瘤风险（ROM）、肿瘤风险、病理实验室工作流程和患者管理的中位时间线。此外，还分别分析了年龄和性别的影响。结果：5年期间共诊断出1157例SG-FNAs。其中，52名女性和33名男性的100名sg - fna被归类为SUMP。69例（69.0%）病例行组织学检查。所有手术随访的ROM为23.2%，嗜瘤细胞/嗜瘤细胞亚型为35.0%，碱性细胞亚型为18.4%。对于男性和女性，所有手术随访的ROMs分别为26.9%和16.2%，嗜瘤细胞/嗜瘤细胞亚型的ROMs分别为40.0%和14.3%，基底细胞亚型的ROMs分别为18.8%和16.7%。结论：在我们的实践中，对SUMP类别性能的5年分析显示，ROM低于MSRSGC参考值。嗜瘤细胞/嗜瘤细胞亚型的ROM高于碱性细胞亚型。ROMs在男性和30-69岁年龄组中最高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Diagnostic Cytopathology 医学-病理学

CiteScore

2.60

自引率

7.70%

发文量

163

审稿时长

3-6 weeks

期刊介绍： Diagnostic Cytopathology is intended to provide a forum for the exchange of information in the field of cytopathology, with special emphasis on the practical, clinical aspects of the discipline. The editors invite original scientific articles, as well as special review articles, feature articles, and letters to the editor, from laboratory professionals engaged in the practice of cytopathology. Manuscripts are accepted for publication on the basis of scientific merit, practical significance, and suitability for publication in a journal dedicated to this discipline. Original articles can be considered only with the understanding that they have never been published before and that they have not been submitted for simultaneous review to another publication.