Current Organoid Culture Systems in Pancreatic Cancer.

IF 2.9 4区医学 Q3 CHEMISTRY, MEDICINAL

Current topics in medicinal chemistry Pub Date : 2025-04-29 DOI:10.2174/0115680266392238250423115420

Lei Liu, Jing Sun, Sheng Chen, Xuechan Tang, Shuai Zhang, Min Wang, Qian Yue, Changqing Zhong, Lianyong Li

引用次数: 0

Abstract

Despite advances in therapeutic regimens, Pancreatic Cancer (PC) still remains an aggressive malignancy characterized by high treatment resistance, mortality, and poor clinical outcome. Hence, there is an urgent need for more effective therapeutic methods to improve the survival of PC patients. Currently, organoid culture systems have emerged as a preclinical research model for studying cancer progression, biology, and treatment responses, bridging the translational gap between in vivo and in vitro models. This review summarized the common culture systems of PC organoids, paving the way for precision medicine in PC.

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当前胰腺癌类器官培养系统。

尽管治疗方案取得了进展，但胰腺癌（PC）仍然是一种侵袭性恶性肿瘤，其特点是治疗耐药性高、死亡率高、临床预后差。因此，迫切需要更有效的治疗方法来提高PC患者的生存率。目前，类器官培养系统已成为研究癌症进展、生物学和治疗反应的临床前研究模型，弥合了体内和体外模型之间的翻译差距。本文对目前常见的类器官培养体系进行了综述，为开展类器官的精准医疗奠定基础。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current topics in medicinal chemistry 医学-医药化学

CiteScore

6.40

自引率

2.90%

发文量

186

审稿时长

3-8 weeks

期刊介绍： Current Topics in Medicinal Chemistry is a forum for the review of areas of keen and topical interest to medicinal chemists and others in the allied disciplines. Each issue is solely devoted to a specific topic, containing six to nine reviews, which provide the reader a comprehensive survey of that area. A Guest Editor who is an expert in the topic under review, will assemble each issue. The scope of Current Topics in Medicinal Chemistry will cover all areas of medicinal chemistry, including current developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, compound diversity measurements, drug absorption, drug distribution, metabolism, new and emerging drug targets, natural products, pharmacogenomics, and structure-activity relationships. Medicinal chemistry is a rapidly maturing discipline. The study of how structure and function are related is absolutely essential to understanding the molecular basis of life. Current Topics in Medicinal Chemistry aims to contribute to the growth of scientific knowledge and insight, and facilitate the discovery and development of new therapeutic agents to treat debilitating human disorders. The journal is essential for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important advances.